|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of endometrium
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Endometrial Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
The CYP1B1 and ERalpha genes may play a role in endometrial cancer and the Arg48Gly (142C > G) -CYP1B1 and 975C > G-ERalpha polymorphisms may be considered as independent, early diagnostic markers in this disease.
|
20492382 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that CYP1B1 Arg48Gly, Ala119Ser and Asn453Ser polymorphisms are not associated with breast cancer risk.
|
20054638 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Endometrial Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
An association of CYP1B1 gene R48G polymorphism with endometrial cancer was found [GG vs. GC+CC: odds ratio (OR)=0.55, 95% confidence interval (CI): 0.42-0.73, P<0.0001; GG vs. CC: OR=0.46, 95% CI: 0.23-0.91, P=0.03].
|
21191305 |
2011 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of endometrium
|
|
0.030 |
GeneticVariation |
BEFREE |
The CYP1B1 and ERalpha genes may play a role in endometrial cancer and the Arg48Gly (142C > G) -CYP1B1 and 975C > G-ERalpha polymorphisms may be considered as independent, early diagnostic markers in this disease.
|
20492382 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of endometrium
|
|
0.030 |
GeneticVariation |
BEFREE |
An association of CYP1B1 gene R48G polymorphism with endometrial cancer was found [GG vs. GC+CC: odds ratio (OR)=0.55, 95% confidence interval (CI): 0.42-0.73, P<0.0001; GG vs. CC: OR=0.46, 95% CI: 0.23-0.91, P=0.03].
|
21191305 |
2011 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that CYP1B1 Arg48Gly, Ala119Ser and Asn453Ser polymorphisms are not associated with breast cancer risk.
|
20054638 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Endometrial Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
To examine the association between six SNPs, CYP1A1(*)2A, CYP1A1(*)2C, CYP1A2(*)1F, CYP1B1 Arg(48)Gly, CYP1B1 Leu(432)Val and CYP3A5*3 and breast cancer risk, therefore, we conducted hospital-based case-control studies in Nagano, Japan and São Paulo, Brazil including 873 pairs (403 Japanese (JJ), 81 Japanese Brazilians (JB) and 389 non-Japanese Brazilians (NJB)).
|
19229255 |
2009 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
To examine the association between six SNPs, CYP1A1(*)2A, CYP1A1(*)2C, CYP1A2(*)1F, CYP1B1 Arg(48)Gly, CYP1B1 Leu(432)Val and CYP3A5*3 and breast cancer risk, therefore, we conducted hospital-based case-control studies in Nagano, Japan and São Paulo, Brazil including 873 pairs (403 Japanese (JJ), 81 Japanese Brazilians (JB) and 389 non-Japanese Brazilians (NJB)).
|
19229255 |
2009 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
For Arg48Gly, individuals with 48GG genotype had a significantly increased risk of lung cancer compared with individuals with 48CC (OR 3.859; 95% CI 2.536-5.87).
|
21674184 |
2012 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
A common C-G-C-C-G-A haplotype for rs2567206-rs2551188-rs2617266-rs10012-rs1056836-rs1800440 showed an inverse association with PCa risk in Hispanic Caucasians (OR = 0.19, P = 0.04, 95% CI = 0.04-0.95) and with aggressive disease status (i.e.
|
18544568 |
2008 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
A common C-G-C-C-G-A haplotype for rs2567206-rs2551188-rs2617266-rs10012-rs1056836-rs1800440 showed an inverse association with PCa risk in Hispanic Caucasians (OR = 0.19, P = 0.04, 95% CI = 0.04-0.95) and with aggressive disease status (i.e.
|
18544568 |
2008 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
For Arg48Gly, individuals with 48GG genotype had a significantly increased risk of lung cancer compared with individuals with 48CC (OR 3.859; 95% CI 2.536-5.87).
|
21674184 |
2012 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association.
|
25115775 |
2014 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association.
|
25115775 |
2014 |
|
rs10012
|
CYP1B1;CYP1B1-AS1
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |