|
rs12333599
|
CYP3A5;ZSCAN25
|
Platelet Count measurement
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
rs1251035592
|
CYP3A5;ZSCAN25
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The SLCO1B1 521T > C and 388A > G variants were found to be relatively common in Chinese patients with essential hyperlipidemia.
|
23263738 |
2013 |
|
rs1474798132
|
CYP3A5;ZSCAN25
|
Tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP2C19 (636 G>A, rs4986893) A allele and AG genotype were associated with decreased susceptibility to TB (P = 0.006, OR= 0.33, 95% CI: 0.15-0.76; and P = 0.005, OR =0.31, 95% CI: 0.14-0.72 respectively), as were the CYP3A5 (6986A>G, rs776746) G allele and particularly homozygous GG (recessive mode) genotype (P = 0.004, OR=0.61, 95% CI: 0.43-0.85; and P=0.002, OR=0.47, 95% CI: 0.29-0.76).
|
22771593 |
2012 |
|
rs1474798132
|
CYP3A5;ZSCAN25
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP2C19*2(G681A), CYP2C19*3(G636A), CYP2D6*4(C188T), CYP2D6*2(C2938T, G4268C), CYP3AP1*3- G44A and CYP3A5*3(A22893G) are the most common polymorphisms detected among Chinese that may influence the efficacy of vinorelbine-based therapies to treat non-small-cell lung cancer (NSCLC).
|
17450472 |
2007 |
|
rs15524
|
CYP3A5;ZSCAN25
|
Epilepsy
|
|
0.010 |
GeneticVariation |
BEFREE |
rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB.
|
26421491 |
2015 |
|
rs200764640
|
CYP3A5;ZSCAN25
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the association between six SNPs, CYP1A1(*)2A, CYP1A1(*)2C, CYP1A2(*)1F, CYP1B1 Arg(48)Gly, CYP1B1 Leu(432)Val and CYP3A5*3 and breast cancer risk, therefore, we conducted hospital-based case-control studies in Nagano, Japan and São Paulo, Brazil including 873 pairs (403 Japanese (JJ), 81 Japanese Brazilians (JB) and 389 non-Japanese Brazilians (NJB)).
|
19229255 |
2009 |
|
rs200764640
|
CYP3A5;ZSCAN25
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the association between six SNPs, CYP1A1(*)2A, CYP1A1(*)2C, CYP1A2(*)1F, CYP1B1 Arg(48)Gly, CYP1B1 Leu(432)Val and CYP3A5*3 and breast cancer risk, therefore, we conducted hospital-based case-control studies in Nagano, Japan and São Paulo, Brazil including 873 pairs (403 Japanese (JJ), 81 Japanese Brazilians (JB) and 389 non-Japanese Brazilians (NJB)).
|
19229255 |
2009 |
|
rs41303343
|
CYP3A5;ZSCAN25
|
ASSAY FOR TACROLIMUS
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
|
30801552 |
2019 |
|
rs4646450
|
CYP3A5;ZSCAN25
|
Hormone measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
|
21533175 |
2011 |
|
rs4646450
|
CYP3A5;ZSCAN25
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP3A5 rs4646450 TT was 17% among ALL cases with FS lower than 28, and 3% in ALL patients without pathological FS (p = 5.60E-03; OR = 6.94 (1.76-27.39)).
|
29970035 |
2018 |
|
rs4646450
|
CYP3A5;ZSCAN25
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP3A5 rs4646450 TT was 17% among ALL cases with FS lower than 28, and 3% in ALL patients without pathological FS (p = 5.60E-03; OR = 6.94 (1.76-27.39)).
|
29970035 |
2018 |
|
rs4646450
|
CYP3A5;ZSCAN25
|
Adult Acute Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP3A5 rs4646450 TT was 17% among ALL cases with FS lower than 28, and 3% in ALL patients without pathological FS (p = 5.60E-03; OR = 6.94 (1.76-27.39)).
|
29970035 |
2018 |
|
rs776746
|
CYP3A5;ZSCAN25
|
ASSAY FOR TACROLIMUS
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
|
30801552 |
2019 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
Our finding suggested that wild-type CYP3A4 rs2242480 (TT) carriers should be more cautious to take tacrolimus when they are coadministrated with calcium channel blockers, and CYP3A5 rs776746 (AA) carriers may need higher tacrolimus dosage when they are in combination with hypertension.
|
30861159 |
2019 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
Overall, no associations were observed between the rs776746 polymorphism and BP/hypertension.
|
21814220 |
2011 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
The CYP3A5 genotype was related with blood pressure in the general population, but the effect on the risk for hypertension in pregnancy has not been evaluated.We compared the allele and genotype frequencies of three functional SNPs in the CYP3A5 (rs776746), CYP3A4 (rs2740574), and CYP21A2 (rs6471) genes between pregnant women who developed hypertension (n = 250) or who remained normotensive (control group, n = 250).
|
20617557 |
2010 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Hypertensive disease
|
|
0.040 |
GeneticVariation |
BEFREE |
We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population.
|
28448186 |
2017 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
CYP2C19 (636 G>A, rs4986893) A allele and AG genotype were associated with decreased susceptibility to TB (P = 0.006, OR= 0.33, 95% CI: 0.15-0.76; and P = 0.005, OR =0.31, 95% CI: 0.14-0.72 respectively), as were the CYP3A5 (6986A>G, rs776746) G allele and particularly homozygous GG (recessive mode) genotype (P = 0.004, OR=0.61, 95% CI: 0.43-0.85; and P=0.002, OR=0.47, 95% CI: 0.29-0.76).
|
22771593 |
2012 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to examine the effect of two gene polymorphisms, one in the CYP2B6 (rs3745274) gene and one in the CYP3A5 (rs776746) gene, on the development of hepatotoxicity in patients treated with anti-TB drugs in a Brazilian Amazon population.
|
25271170 |
2015 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation |
BEFREE |
Eight variants in five candidate genes were examined for the risk of stroke, including the SG13S32 (rs9551963), SG13S42 (rs4769060), SG13S89 (rs4769874), and SG13S114 (rs10507391) variants of the 5-lipoxygenase activating protein (ALOX5AP) gene, the G860A (rs751141) variant of the soluble epoxide hydrolase (EPHX2) gene, the A1075C (rs1057910) variant of the CYP2C9*2 gene, the C430T (rs1799853) variant of the CYP2C9*3 gene, and the A6986G (rs776746) variant of the CYP3A5 gene.
|
24368493 |
2014 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation |
BEFREE |
The interaction between rs10507391 and rs776746 increases the susceptibility to ischemic stroke and is associated with atherothrombotic events in stroke patients.
|
25534367 |
2015 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Carcinogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
Emerging evidences suggest that CYP3A5*3 (rs776746 A>G) polymorphism may play a role in the etiology of carcinogenesis and affect an individual's susceptibility to cancer in humans, but individually published studies showed inconclusive results.
|
23584898 |
2013 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
The interaction between rs10507391 and rs776746 increases the susceptibility to ischemic stroke and is associated with atherothrombotic events in stroke patients.
|
25534367 |
2015 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Variation of the CYP3A5*3 (rs776746 A > G) can lead to oxidation and inactivation of testosterone, which may result in individual susceptibility to prostate cancer.
|
29970707 |
2018 |
|
rs776746
|
CYP3A5;ZSCAN25
|
Leukopenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Although univariate analysis in all patients did not reveal any association at first, further analysis indicated that rs776746 is significantly associated with severe neutropenia in subgroup of breast cancer patients with normal baseline ANC (≥2.0 × 10(9)/L).
|
23143606 |
2013 |