NQO1, NAD(P)H quinone dehydrogenase 1, 1728

N. diseases: 368; N. variants: 8
Disease: Adenocarcinoma of lung (disorder) ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800566
rs1800566
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.020 GeneticVariation BEFREE In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians. 16702380 2006
dbSNP: rs1800566
rs1800566
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.020 GeneticVariation BEFREE In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and 152 control subjects. 12163326 2002