FCGR3B, Fc fragment of IgG receptor IIIb, 2215

N. diseases: 291; N. variants: 8
Disease: Lupus Erythematosus, Systemic ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs560051377
rs560051377
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.040 GeneticVariation BEFREE Despite LD between FCGR3B CNV and a variant in FcgammaRIIB (I232T) which abolishes inhibitory function, both reduced CN of FCGR3B and homozygosity of the FcgammaRIIB-232T allele were individually strongly associated with SLE risk. 20508037 2010
dbSNP: rs560051377
rs560051377
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.040 GeneticVariation BEFREE Recent work has enhanced our understanding of the mechanism of action of the FcgammaRIIB I232T polymorphism and the overall role of this receptor in SLE. 20146709 2010
dbSNP: rs560051377
rs560051377
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.040 GeneticVariation BEFREE We recently identified a single-nucleotide polymorphism encoding a non-synonymous substitution, Ile232Thr (I232T), of FCGR2B and its association with SLE in Japanese and in Thais. 14651519 2004
dbSNP: rs560051377
rs560051377
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.040 GeneticVariation BEFREE These results demonstrate the association of a new polymorphism of FCGR2B (I232T) with susceptibility to SLE in the Japanese. 12115230 2002