FLT3, fms related receptor tyrosine kinase 3, 2322

N. diseases: 270; N. variants: 54
Disease: Leukemia, Myelocytic, Acute ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519764
rs1057519764
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.710 GeneticVariation BEFREE Targeted next-generation sequencing at the time of AML progression on gilteritinib identified treatment-emergent mutations that activate RAS/MAPK pathway signaling, most commonly in <i>NRAS</i> or <i>KRAS.</i> Less frequently, secondary <i>FLT3</i>-F691L gatekeeper mutations or <i>BCR-ABL1</i> fusions were identified at progression. 31088841 2019
dbSNP: rs1057519764
rs1057519764
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
dbSNP: rs1057519764
rs1057519764
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012