FLT3, fms related receptor tyrosine kinase 3, 2322

N. diseases: 270; N. variants: 54
Disease: Leukemia, Myelocytic, Acute ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs376588714
rs376588714
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500 2014
dbSNP: rs376588714
rs376588714
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109 2013
dbSNP: rs376588714
rs376588714
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
dbSNP: rs376588714
rs376588714
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.710 GeneticVariation BEFREE Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). 15345593 2005