ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: Non-Small Cell Lung Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519784
rs1057519784
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE Exploring the crizotinib resistance mechanism of NSCLC with the L1196M mutation using molecular dynamics simulation. 29067524 2017
dbSNP: rs1057519784
rs1057519784
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE Alectinib is a new generation ALK inhibitor with activity against the gatekeeper L1196M mutation that showed remarkable activity in a phase I/II study with echinoderm microtubule associated protein-like 4 (EML4)--anaplastic lymphoma kinase (ALK) non-small cell lung cancer (NSCLC) patients. 24952482 2014