ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: Non-Small Cell Lung Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs281864719
rs281864719
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE F1174V mutation alters the ALK active conformation in response to Crizotinib in NSCLC: Insight from molecular simulations. 28622610 2017
dbSNP: rs281864719
rs281864719
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.020 GeneticVariation BEFREE Here, we identified a novel secondary acquired NSCLC ALK F1174V mutation by comprehensive next-generation sequencing in one ALK+ NSCLC patient who progressed on crizotinib after a prolonged partial response to crizotinib. 24736079 2014