GPX1, glutathione peroxidase 1, 2876

N. diseases: 290; N. variants: 12
Disease: Prostate carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1050450
rs1050450
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE The present meta-analysis provides evidence that the GPX1 rs1050450 C > T polymorphism leads to an increased risk of BC but not the risk of PCa. 23975365 2014
dbSNP: rs1050450
rs1050450
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer. 24610081 2014
dbSNP: rs1050450
rs1050450
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE However, the GPx1 rs1050450 allele T in association with prostate cancer recorded a significantly higher GPx activity compared to the controls. 23363810 2012
dbSNP: rs1050450
rs1050450
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
CUI: C0600139
Disease:
Prostate carcinoma 		0.040 GeneticVariation BEFREE We evaluated potential associations between gene variants that result in reduced neutralization of reactive oxygen species (ROS; MnSOD Ala-16Val, CAT -262 C>T, and GPX1 Pro200Leu) and prostate cancer risk among 724 men with incident prostate cancer who participated in the Carotene and Retinol Efficacy Trial (CARET) cohort, a randomized trial for the prevention of lung cancer among men with a history of smoking and/or asbestos exposure. 17548672 2007