|
rs11549465
|
HIF1A;HIF1A-AS3
|
Hyperglycemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the relative resistance of the <i>HIF-1A</i> Pro582Ser polymorphism to the repressive effect of hyperglycemia is due to the transactivation activity rather than the protein stability of HIF-1<i>α</i>.
|
31214621 |
2019 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a protective effect of <i>HIF-1A</i> Pro582Ser against developing severe DR with a risk reduction of 95%, even when adjusting for known risk factors for DR such as diabetes duration, hyperglycemia, and hypertension.
|
31214621 |
2019 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a protective effect of <i>HIF-1A</i> Pro582Ser against developing severe DR with a risk reduction of 95%, even when adjusting for known risk factors for DR such as diabetes duration, hyperglycemia, and hypertension.
|
31214621 |
2019 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs1957757
|
HIF1A;HIF1A-AS3
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, this study provides additional evidence that genetic variation of the PECAM1 rs1867624 and HIF1A rs2057482 can mediate lipid levels in MI patients.
|
30678728 |
2019 |
|
rs41508050
|
HIF1A;HIF1A-AS3
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In the meta-analysis of HIF1A, the rs11549465 C > T and rs10873142 T > C polymorphisms, but not rs2057482, rs11549467, and rs41508050, were correlated with overall MI or CAD risk.
|
30678728 |
2019 |
|
rs41508050
|
HIF1A;HIF1A-AS3
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
In the meta-analysis of HIF1A, the rs11549465 C > T and rs10873142 T > C polymorphisms, but not rs2057482, rs11549467, and rs41508050, were correlated with overall MI or CAD risk.
|
30678728 |
2019 |
|
rs763538721
|
HIF1A;HIF1A-AS3
|
Thyroid carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, glycolysis-related enzymes, such as LDHA and PKM2, were upregulated in BRAF V600E </span>mutant thyroid cancer specimens, thereby promoting glycolysis.
|
30768848 |
2019 |
|
rs763538721
|
HIF1A;HIF1A-AS3
|
Thyroid Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, glycolysis-related enzymes, such as LDHA and PKM2, were upregulated in BRAF V600E </span>mutant thyroid cancer specimens, thereby promoting glycolysis.
|
30768848 |
2019 |
|
rs763538721
|
HIF1A;HIF1A-AS3
|
Malignant neoplasm of thyroid
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, glycolysis-related enzymes, such as LDHA and PKM2, were upregulated in BRAF V600E </span>mutant thyroid cancer specimens, thereby promoting glycolysis.
|
30768848 |
2019 |
|
rs10873142
|
HIF1A;HIF1A-AS3
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
To the best of our knowledge, this is the first case-control study uncovering that the <i>HIF1A</i> gene rs10873142 polymorphism increases the risk of COPD in a Chinese Han population.
|
29339421 |
2018 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Neural Tube Defects
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of this study show that Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms may play a role in NTDs.
|
30672442 |
2018 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with rs11549465 CT + TT had higher COPD risk than those with the CC genotype.
|
28865600 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified <i>HIF1A Pro582Ser T</i> allele and <i>C</i>/<i>T</i> genotype as well as <i>AKNA -1372C>A</i> polymorphism A/A genotype as genetic factors associated with pSS.
|
28484714 |
2017 |
|
rs11549467
|
HIF1A;HIF1A-AS3
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
HIF-1α rs11549467 polymorphism may be associated with COPD risk.
|
28865600 |
2017 |
|
rs142179458
|
HIF1A;HIF1A-AS3
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Subtype analysis performed for patient subgroups defined by ER, PR, and HER2 status suggested additional associations of the <i>NOTCH3</i> SNP rs200504060 and the <i>HIF1A</i> SNP rs142179458 with breast cancer risk.
|
28775167 |
2017 |
|
rs142179458
|
HIF1A;HIF1A-AS3
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Subtype analysis performed for patient subgroups defined by ER, PR, and HER2 status suggested additional associations of the <i>NOTCH3</i> SNP rs200504060 and the <i>HIF1A</i> SNP rs142179458 with breast cancer risk.
|
28775167 |
2017 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs2057482
|
HIF1A;HIF1A-AS2;HIF1A-AS3
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549465
|
HIF1A;HIF1A-AS3
|
Endometriosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between the presence of endometriosis and SNPs in PLGF (rs2268614), HIF-1α (rs11549465), and VEGFR1 (rs9582036) genes lost statistical significance after multiple testing.
|
26773192 |
2016 |