|
rs9272105
|
HLA-DQA1
|
Liver carcinoma
|
|
0.810 |
GeneticVariation |
BEFREE |
Through stepwise regression analysis, HBV genotype, the 11 mutations, HLA-DQ/DR SNPs, and the interaction of rs9272105 with mutation A1752G were all entered into the HCC prediction model, and the area under the curve for the panel including the HLA-DQ/DR SNPs, HBV genotype and mutations was 0.840.
|
26568165 |
2015 |
|
rs9272346
|
HLA-DQA1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASCAT |
Of these, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults (P-value = 2.2E-08) with consistent evidence in the more heterogeneous group of adults and children (P-value = 1.0E-04).
|
23181788 |
2012 |
|
rs9272346
|
HLA-DQA1
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.810 |
GeneticVariation |
BEFREE |
Our results showed significant association of 10 single nucleotide polymorphisms (SNPs) with T1D at p<0.01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more SNPs showed their association at 0.01<p<0.05 in Pakistani population.
|
25661663 |
2015 |
|
rs9272346
|
HLA-DQA1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Of these, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults (P-value = 2.2E-08) with consistent evidence in the more heterogeneous group of adults and children (P-value = 1.0E-04).
|
23181788 |
2012 |
|
rs9272346
|
HLA-DQA1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
Of these, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults (P-value = 2.2E-08) with consistent evidence in the more heterogeneous group of adults and children (P-value = 1.0E-04).
|
23181788 |
2012 |
|
rs17843604
|
HLA-DQA1
|
Asthma
|
|
0.800 |
GeneticVariation |
GWASCAT |
Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.
|
30578877 |
2019 |
|
rs17843604
|
HLA-DQA1
|
Asthma
|
|
0.800 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Membranous glomerulonephritis
|
|
0.800 |
GeneticVariation |
GWASDB |
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
|
21323541 |
2011 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Lupus Erythematosus, Systemic
|
|
0.800 |
GeneticVariation |
GWASCAT |
Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry.
|
26316170 |
2016 |
|
rs6927022
|
HLA-DQA1;LOC107986589
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs9272143
|
HLA-DQA1
|
Cervix carcinoma
|
|
0.720 |
GeneticVariation |
GWASCAT |
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.
|
28806749 |
2017 |
|
rs9272143
|
HLA-DQA1
|
Cervix carcinoma
|
|
0.720 |
GeneticVariation |
GWASCAT |
Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)).
|
23482656 |
2013 |
|
rs9272143
|
HLA-DQA1
|
cervical cancer
|
|
0.720 |
GeneticVariation |
GWASDB |
Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)).
|
23482656 |
2013 |
|
rs9272143
|
HLA-DQA1
|
cervical cancer
|
|
0.720 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
|
rs9272143
|
HLA-DQA1
|
cervical cancer
|
|
0.720 |
GeneticVariation |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
|
rs9272143
|
HLA-DQA1
|
Cervix carcinoma
|
|
0.720 |
GeneticVariation |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
|
rs9272143
|
HLA-DQA1
|
Cervix carcinoma
|
|
0.720 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Autoimmune Chronic Hepatitis
|
|
0.710 |
GeneticVariation |
BEFREE |
We associated AIH with a variant in the major histocompatibility complex region at rs2187668 (P = 1.5 × 10(-78)).
|
24768677 |
2014 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Autoimmune Chronic Hepatitis
|
|
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.
|
24768677 |
2014 |
|
rs9272219
|
HLA-DQA1
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation |
GWASDB |
Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.
|
21653640 |
2011 |
|
rs9272219
|
HLA-DQA1
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
rs9272219
|
HLA-DQA1
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation |
BEFREE |
We found significant association between rs9272219 and RA of Chinese population (OR 0.494, 95% confidence interval [95% CI] 0.354-0.688, P = 0 and OR 2.541, 95% CI 1.695-3.808, P = 0, respectively).
|
25550865 |
2014 |
|
rs9272729
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Membranous glomerulonephritis
|
|
0.710 |
GeneticVariation |
BEFREE |
In GWAS, lead variants in known loci [rs9272729, HLA-DQA1, odds ratio (OR) = 7.3 per risk allele, P = 5.9 × 10<sup>-27</sup> and rs17830558, PLA2R1, OR = 2.2, P = 1.9 × 10<sup>-8</sup>] were significantly associated with MN.
|
27333618 |
2017 |
|
rs114549185
|
HLA-DQA1
|
Sarcoidosis
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |
|
rs114798579
|
HLA-DQA1
|
Sarcoidosis
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |