|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Autoimmune Chronic Hepatitis
|
|
0.710 |
GeneticVariation |
BEFREE |
We associated AIH with a variant in the major histocompatibility complex region at rs2187668 (P = 1.5 × 10(-78)).
|
24768677 |
2014 |
|
rs9272729
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Membranous glomerulonephritis
|
|
0.710 |
GeneticVariation |
BEFREE |
In GWAS, lead variants in known loci [rs9272729, HLA-DQA1, odds ratio (OR) = 7.3 per risk allele, P = 5.9 × 10<sup>-27</sup> and rs17830558, PLA2R1, OR = 2.2, P = 1.9 × 10<sup>-8</sup>] were significantly associated with MN.
|
27333618 |
2017 |
|
rs9276370
|
HLA-DQA2
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Idiopathic Membranous Glomerulonephritis
|
|
0.040 |
GeneticVariation |
BEFREE |
Our pooled analysis showed a significant association between rs2187668-(A) allele and iMN susceptibility, and the intervention of this mutation might bring new therapeutic strategy for iMN.
|
30383665 |
2018 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Idiopathic Membranous Glomerulonephritis
|
|
0.040 |
GeneticVariation |
BEFREE |
Even under dominant model, the two SNPs were still significantly associated with IMN (P = 3.50×10-3 for rs28383345 and P = 6.55×10-5 for rs2187668).
|
28685717 |
2017 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Idiopathic Membranous Glomerulonephritis
|
|
0.040 |
GeneticVariation |
BEFREE |
We believe this will be a valuable technique for determining the genotype of rs2187668 and rs4664308 and for assessing individual susceptibility to IMN.
|
23194743 |
2013 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Idiopathic Membranous Glomerulonephritis
|
|
0.040 |
GeneticVariation |
BEFREE |
Allelic frequency distributions for SNP rs2187668 within HLA-DQA1 were significantly different between the iMN and control groups.
|
28849274 |
2018 |
|
rs1071630
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-sensitive nephrotic syndrome
|
|
0.020 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs1071630
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-sensitive nephrotic syndrome
|
|
0.020 |
GeneticVariation |
BEFREE |
Two of these SNPs-the missense variants C34Y (rs1129740) and F41S (rs1071630) in HLA-DQA1-were replicated in an independent cohort of children of white European ancestry with SSNS (100 cases and ≤589 controls; P=1.42×10(-17)).
|
25349203 |
2015 |
|
rs1129740
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-sensitive nephrotic syndrome
|
|
0.020 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs1129740
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-sensitive nephrotic syndrome
|
|
0.020 |
GeneticVariation |
BEFREE |
Two of these SNPs-the missense variants C34Y (rs1129740) and F41S (rs1071630) in HLA-DQA1-were replicated in an independent cohort of children of white European ancestry with SSNS (100 cases and ≤589 controls; P=1.42×10(-17)).
|
25349203 |
2015 |
|
rs9272785
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))--both located between HLA-DQA1 and HLA-DRB1--and a missense variant encoding p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14).
|
26829749 |
2016 |
|
rs9272785
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
While no significant association was found in the whole samples, a SNP of HLA-DQA1, rs9272785, showed suggestive association within the young-onset TB subgroup (onset at 20-40 years of age, N = 396).
|
30553063 |
2019 |
|
rs1071630
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Leprosy
|
|
0.010 |
GeneticVariation |
BEFREE |
We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54).
|
20617178 |
2010 |
|
rs1071630
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid resistant nephrotic syndrome of childhood
|
|
0.010 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs1071630
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-resistant nephrotic syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs1129740
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid resistant nephrotic syndrome of childhood
|
|
0.010 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs1129740
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Steroid-resistant nephrotic syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The 2 HLA-DQA1 variants were significantly associated with SSNS in African American children (C34Y: P=5.7 × 10<sup>-11</sup>; OR, 3.53; 95% CI, 2.33-5.42; F41S: P=1.2 × 10<sup>-13</sup>; OR, 4.08; 95% CI, 2.70-6.28), but not with SRNS (C34Y: P=0.6; F41S: P=0.2).
|
29277510 |
2018 |
|
rs12722039
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Hyperthyroidism
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of genotypes (HLA DRB1*03, DQA1*05, DQB1*02; CTLA4 49A/G, CT60 A/G; PTPN22 C/T) in relation to phenotypes (age, sex, severity (clinical, biochemical, and immunological)) of hyperthyroidism and environmental factors (smoking, stress questionnaires).
|
22968483 |
2012 |
|
rs12722039
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Celiac Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate CTLA-4 exon 1 polymorphism (position 49 A/G) in patients with coeliac disease.
|
10189842 |
1998 |
|
rs12722051
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Systemic onset juvenile chronic arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional analysis controlling for the effect of rs151043342 found that rs12722051 independently influenced sJIA risk [P = 1.0 × 10(-5), OR 0.7 (0.6, 0.8)].
|
26598658 |
2015 |
|
rs1744
|
HLA-DQA2
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
The interactions among rs1744 6614, BMI and duration of diabetes (OR: 2.63, 95%CI: 1.23-4.31) were also observed.
|
28860538 |
2017 |
|
rs1744
|
HLA-DQA2
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The interactions among rs1744 6614, BMI and duration of diabetes (OR: 2.63, 95%CI: 1.23-4.31) were also observed.
|
28860538 |
2017 |
|
rs2187668
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Autoimmune hepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated AIH with a variant in the major histocompatibility complex region at rs2187668 (P = 1.5 × 10(-78)).
|
24768677 |
2014 |
|
rs28383345
|
HLA-DQA1;HLA-DQA2;LOC107986589
|
Idiopathic Membranous Glomerulonephritis
|
|
0.010 |
GeneticVariation |
BEFREE |
Even under dominant model, the two SNPs were still significantly associated with IMN (P = 3.50×10-3 for rs28383345 and P = 6.55×10-5 for rs2187668).
|
28685717 |
2017 |