HPR, haptoglobin-related protein, 3250

N. diseases: 94; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs75444904
rs75444904
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.700 GeneticVariation GWASCAT Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. 29572449 2018
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0518015
Disease:
Hemoglobin measurement 		A 0.700 GeneticVariation GWASCAT Connecting genetic risk to disease end points through the human blood plasma proteome. 28240269 2017
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		A 0.700 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316 2012
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0523465
Disease:
Serum albumin measurement 		0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs34042070
rs34042070
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0523465
Disease:
Serum albumin measurement 		0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
dbSNP: rs3794695
rs3794695
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0523465
Disease:
Serum albumin measurement 		0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		A 0.700 GeneticVariation GWASDB Biological, clinical and population relevance of 95 loci for blood lipids. 20686565 2010
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE Under codominant and recessive models, rs2000999 was significantly associated with TC and LDL-C levels in the T2D group and in controls without T2D. 31574854 2019
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE The genetic variant rs2000999 was not associated with diabetic macrovascular diseases but showed an association with metabolic traits and serum Hp levels in Chinese patients with type 2 diabetes. 30366827 2019
dbSNP: rs2000999
rs2000999
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.010 GeneticVariation BEFREE Recently, studies have shown significant association between the rs2000999 polymorphism in the haptoglobin-encoding gene (HP) and low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels, which are important risk factors for cardiovascular diseases. 31574854 2019
dbSNP: rs75444904
rs75444904
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0011881
Disease:
Diabetic Nephropathy 		0.010 GeneticVariation BEFREE The rs75444904 variant was associated with DKD progression (OR = 1.77, P = 0.014) independent of traditional risk factors. 29572449 2018
dbSNP: rs75444904
rs75444904
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.010 GeneticVariation BEFREE In an additional validation-cohort of EA (410 end-stage renal disease (ESRD) cases and 1308 controls), rs75444904 was associated with ESRD (OR = 1.22, P = 0.036). 29572449 2018
dbSNP: rs75444904
rs75444904
Entrez Id: 3250;54957
Gene Symbol: HPR;TXNL4B
HPR;TXNL4B
CUI: C2316810
Disease:
Chronic kidney disease stage 5 		0.010 GeneticVariation BEFREE In an additional validation-cohort of EA (410 end-stage renal disease (ESRD) cases and 1308 controls), rs75444904 was associated with ESRD (OR = 1.22, P = 0.036). 29572449 2018