Disease: Hormone refractory prostate cancer ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1047303
rs1047303
Entrez Id: 3283
Gene Symbol: HSD3B1
HSD3B1
CUI: C1328504
Disease:
Hormone refractory prostate cancer 		0.010 GeneticVariation BEFREE A common 1245 A→C missense-encoding single nucleotide polymorphism in HSD3B1 (rs1047303), the gene that encodes this enzyme, leads to a more stable protein that is resistant to degradation and thus increased production of potent androgens from adrenal precursors, facilitating castration-resistant PCa development. 31271415 2019