DisGeNET - a database of gene-disease associations

APOB, apolipoprotein B, 338

N. diseases: 339; N. variants: 122

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

21943158

2011

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1168443
Disease:

Pseudocholinesterase Measurement

0.700

GeneticVariation

GWASDB

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

21943158

2011

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0523465
Disease:

Serum albumin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

22286219

2012

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs10199768

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0428474
Disease:

Serum LDL cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASCAT

The impact of low-frequency and rare variants on lipid levels.

25961943

2015

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.800

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.800

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0392885
Disease:

High density lipoprotein measurement

0.700

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0428474
Disease:

Serum LDL cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202236
Disease:

Triglycerides measurement

0.700

GeneticVariation

GWASCAT

Genetic analyses of diverse populations improves discovery for complex traits.

31217584

2019

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0523465
Disease:

Serum albumin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

22286219

2012

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202236
Disease:

Triglycerides measurement

0.700

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs1041968

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0392885
Disease:

High density lipoprotein measurement

0.700

GeneticVariation

GWASCAT

A large electronic-health-record-based genome-wide study of serum lipids.

29507422

2018

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:

Low density lipoprotein cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0428474
Disease:

Serum LDL cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1956346
Disease:

Coronary Artery Disease

0.030

GeneticVariation

BEFREE

Individually, the single SNPs were not associated with CAD except APOB rs1042031 and FTO rs993969 (p = 0.01 and 0.009 respectively).

28167353

2017

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1956346
Disease:

Coronary Artery Disease

0.030

GeneticVariation

BEFREE

Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.

28705542

2019

dbSNP:

rs1042031

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C1956346
Disease:

Coronary Artery Disease

0.030

GeneticVariation

BEFREE

This study aimed to verify the possible influence of apolipoprotein B (ApoB: rs1042031 and rs693) and angiotensin-converting enzyme (ACE-ID: rs1799752) genotypes on the lipid profile and functional aerobic capacity, respectively, after an aerobic interval training (AIT) program in patients with CAD and/or cardiovascular risk factors.

29846435

2018