FAS, Fas cell surface death receptor, 355

N. diseases: 754; N. variants: 47
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		A 0.800 GeneticVariation GWASCAT A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. 24292274 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		A 0.800 GeneticVariation GWASDB A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. 24292274 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0010346
Disease:
Crohn Disease 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0033860
Disease:
Psoriasis 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0009324
Disease:
Ulcerative Colitis 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		A 0.700 GeneticVariation GWASCAT A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. 24292274 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0008313
Disease:
Cholangitis, Sclerosing 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0038013
Disease:
Ankylosing spondylitis 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C2674950
Disease:
LUNG CANCER, SUSCEPTIBILITY TO 		A 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06-1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04-1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. 27524883 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE The present study investigated the association between -1377 G/A (rs2234767) and -670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt -124 A/G (rs5030772) and -844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. 23326385 2013
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06-1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04-1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. 27524883 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE The present study investigated the association between -1377 G/A (rs2234767) and -670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt -124 A/G (rs5030772) and -844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. 23326385 2013
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0152018
Disease:
Esophageal carcinoma 		0.020 GeneticVariation BEFREE Significant association among the Fas -670 A/G (rs1800682) polymorphism and esophageal cancer, hepatocellular carcinoma, and prostate cancer susceptibility: a meta-analysis. 25085585 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0302592
Disease:
Cervix carcinoma 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. 29734947 2018
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C4048328
Disease:
cervical cancer 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0302592
Disease:
Cervix carcinoma 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0007847
Disease:
Malignant tumor of cervix 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0152018
Disease:
Esophageal carcinoma 		0.020 GeneticVariation BEFREE The case-control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. 26819081 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C4048328
Disease:
cervical cancer 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0007847
Disease:
Malignant tumor of cervix 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. 25645050 2015