rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
0.740
GeneticVariation
BEFREE
Although targeted therapy involving tyrosine kinase inhibitors (TKIs) such as imatinib mesylate is highly effective for gastrointestinal stromal tumor carrying V560G c-kit mutation, it does not show much potential for targeting wild-type KIT (WT-KIT).
26428235
2016
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
0.740
GeneticVariation
BEFREE
Molecular study revealed a mutation at the juxtamembrane domain of exon 12 in PDGFRA gene with GTC to GAC transition at codon 561 (V561D ), as shown in the previous mutational studies on gastrointestinal stromal tumor (GIST ).
15894928
2005
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
0.740
GeneticVariation
BEFREE
The patient was found to carry a germline PDGFRA mutation (V561D ) in the heterozygote state; it has only been seen rarely before and only in the somatic state in sporadic GIST s.
17566086
2007
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
0.740
GeneticVariation
BEFREE
The single missense mutation (Val560Asp ) is very similar to the only other missense mutation reported in GIST s (Val599Asp ).
10086344
1999
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
A
0.740
GeneticVariation
CLINVAR
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
19164557
2009
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
A
0.740
GeneticVariation
CLINVAR
An update on molecular genetics of gastrointestinal stromal tumours.
16731599
2006
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
G
0.740
GeneticVariation
CLINVAR
The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment.
19737976
2009
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
A
0.740
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
G
0.740
GeneticVariation
CLINVAR
An update on molecular genetics of gastrointestinal stromal tumours.
16731599
2006
rs121913521
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
Gastrointestinal Stromal Tumors
G
0.740
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014