KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Disease: Non-Small Cell Lung Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		G 0.790 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		G 0.790 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Somatic PTPN11 mutations in childhood acute myeloid leukaemia. 15842656 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome. 17704260 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		G 0.790 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. 19029981 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		T 0.790 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 GeneticVariation CLINVAR A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. 20609353 2010
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 CausalMutation CLINVAR KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways. 21169357 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 GeneticVariation CLINVAR Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. 21398618 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 GeneticVariation CLINVAR Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. 22235099 2012
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.790 GeneticVariation BEFREE NSCLC cell lines with mutant KRas-Gly12Asp had activated phosphatidylinositol 3-kinase (PI-3-K) and mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) signaling, whereas those with mutant KRas-Gly12Cys or mutant KRas-Gly12Val had activated Ral signaling and decreased growth factor-dependent Akt activation. 22247021 2012
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 GeneticVariation CLINVAR Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. 22897852 2012
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.790 GeneticVariation BEFREE Using genetically engineered mouse models (GEMMs) for human non-small-cell lung cancer (NSCLC), we found that deletion of the essential autophagy gene, Atg7, in KRAS(G12D)-driven NSCLC inhibits tumor growth and converts adenomas and adenocarcinomas to benign oncocytomas characterized by the accumulation of respiration-defective mitochondria. 23959381 2013
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		A 0.790 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014