KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Disease: Colorectal Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335 2011
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465 2010
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. 20921462 2010
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683 2009
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. 19679400 2009
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. 18316791 2008
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717 2006
dbSNP: rs121913527
rs121913527
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. 16361624 2005