LIPC, lipase C, hepatic type, 3990

N. diseases: 120; N. variants: 95
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800588
rs1800588
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.020 GeneticVariation BEFREE 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. 23874450 2013
dbSNP: rs1800588
rs1800588
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.020 GeneticVariation BEFREE The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease. 19558527 2009
dbSNP: rs1800588
rs1800588
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1956346
Disease:
Coronary Artery Disease 		0.030 GeneticVariation BEFREE 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. 23874450 2013
dbSNP: rs1800588
rs1800588
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1956346
Disease:
Coronary Artery Disease 		0.030 GeneticVariation BEFREE A family-based quantitative transmission disequilibrium test (QTDT) revealed significant association between variant rs1800588 in LIPC and HDL-C in the GeneQuest population (P = 0.0067), which may account for the minor QTL on 15q22. 20075193 2010
dbSNP: rs1800588
rs1800588
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1956346
Disease:
Coronary Artery Disease 		0.030 GeneticVariation BEFREE The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease. 19558527 2009
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1077835
rs1077835
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1077835
rs1077835
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa. 31675503 2019
dbSNP: rs2070895
rs2070895
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7182229
rs7182229
Entrez Id: 3990;8854;101928694
Gene Symbol: LIPC;ALDH1A2;LIPC-AS1
LIPC;ALDH1A2;LIPC-AS1
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1445957
Disease:
Serum total cholesterol measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1077835
rs1077835
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1077835
rs1077835
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs1077835
rs1077835
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs11631342
rs11631342
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0524620
Disease:
Metabolic Syndrome X 		0.700 GeneticVariation GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898 2018
dbSNP: rs17269348
rs17269348
Entrez Id: 3990
Gene Symbol: LIPC
LIPC
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs17269348
rs17269348
Entrez Id: 3990
Gene Symbol: LIPC
LIPC
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs261334
rs261334
Entrez Id: 3990;8854;101928694
Gene Symbol: LIPC;ALDH1A2;LIPC-AS1
LIPC;ALDH1A2;LIPC-AS1
CUI: C0202236
Disease:
Triglycerides measurement 		G 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs261334
rs261334
Entrez Id: 3990;8854;101928694
Gene Symbol: LIPC;ALDH1A2;LIPC-AS1
LIPC;ALDH1A2;LIPC-AS1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		G 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs6494005
rs6494005
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0524620
Disease:
Metabolic Syndrome X 		0.700 GeneticVariation GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898 2018
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.700 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs1077834
rs1077834
Entrez Id: 3990;8854
Gene Symbol: LIPC;ALDH1A2
LIPC;ALDH1A2
CUI: C1445957
Disease:
Serum total cholesterol measurement 		T 0.700 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017