LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs75692336
rs75692336
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		A 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs76000021
rs76000021
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs9365169
rs9365169
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		G 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs6926458
rs6926458
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		G 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs6926458
rs6926458
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		G 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs73596816
rs73596816
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		A 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs73596816
rs73596816
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		A 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		C 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs191555775
rs191555775
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs191555775
rs191555775
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs191555775
rs191555775
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs185882981
rs185882981
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		A 0.700 GeneticVariation GWASCAT A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure. 30108283 2018
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1861172
Disease:
Venous Thromboembolism 		0.010 GeneticVariation BEFREE Aim of the study was to investigate the role of LPA gene KIV-2 size polymorphism and single nucleotide polymorphisms (SNPs) (rs1853021, rs1800769, rs3798220, rs10455872) in modulating VTE susceptibility. 26900838 2016
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1861172
Disease:
Venous Thromboembolism 		0.010 GeneticVariation BEFREE Aim of the study was to investigate the role of LPA gene KIV-2 size polymorphism and single nucleotide polymorphisms (SNPs) (rs1853021, rs1800769, rs3798220, rs10455872) in modulating VTE susceptibility. 26900838 2016
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.090 GeneticVariation BEFREE Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls. 28705542 2019
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1704436
Disease:
Peripheral Arterial Diseases 		0.010 GeneticVariation BEFREE Analyses in three independent populations showed significant associations of Lp(a) concentrations, LMW apo(a) phenotypes, and rs10455872 with PAD. 24760552 2014
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		G 0.770 GeneticVariation GWASCAT Association analyses based on false discovery rate implicate new loci for coronary artery disease. 28714975 2017
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation BEFREE Being a carrier of rs10455872 did not affect risk of type 2 diabetes. 24622370 2013
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.090 GeneticVariation BEFREE Both allelic and genotypic associations of rs964184, rs2895811 and rs3798220 with CAD were significant, regardless of adjustment for covariates of gender, age, hypertension, type 2 diabetes, blood lipid profiles and smoking. 26740236 2016
dbSNP: rs3798220
rs3798220
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0003507
Disease:
Aortic Valve Stenosis 		0.010 GeneticVariation BEFREE Both LPA variants were associated with AS, with a per risk allele odds ratio of 1.34 (95% CI, 1.23-1.47; P = 1.7 × 10-10) for rs10455872 and 1.31 (95% CI, 1.09-1.58; P = 3.6 × 10-3) for rs3798220 after adjusting for age, age2, and sex. 29128868 2018
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0003507
Disease:
Aortic Valve Stenosis 		0.030 GeneticVariation BEFREE Both LPA variants were associated with AS, with a per risk allele odds ratio of 1.34 (95% CI, 1.23-1.47; P = 1.7 × 10-10) for rs1</span>0455872 and 1.31 (95% CI, 1.09-1.58; P = 3.6 × 10-3) for rs3798220 after adjusting for age, age2, and sex. 29128868 2018