MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Disease: Glaucoma, Primary Open Angle ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799750
rs1799750
Entrez Id: 4312;100288077
Gene Symbol: MMP1;WTAPP1
MMP1;WTAPP1
CUI: C0339573
Disease:
Glaucoma, Primary Open Angle 		0.020 GeneticVariation BEFREE Subgroup analyses showed that the rs1799750 was significantly associated with primary angle closure glaucoma under homozygote (OR = 2.23, 95% CI 1.03-4.83, p = 0.043) and allelic (OR = 1.61, 95% CI 1.07-2.42, P = 0.021) models, while it was significantly associated with primary open angle glaucoma (OR = 1.64, 95% CI 1.05-2.56, p = 0.030) and exfoliation glaucoma (OR = 1.42, 95% CI 1.02-1.97, p = 0.036) under recessive models. 27428613 2017
dbSNP: rs1799750
rs1799750
Entrez Id: 4312;100288077
Gene Symbol: MMP1;WTAPP1
MMP1;WTAPP1
CUI: C0339573
Disease:
Glaucoma, Primary Open Angle 		0.020 GeneticVariation BEFREE Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan. 23441116 2013