MT2A, metallothionein 2A, 4502

N. diseases: 117; N. variants: 3
Disease: Malignant neoplasm of breast ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28366003
rs28366003
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Our results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased BC risk in Northwest Chinese Han population. 28228606 2017
dbSNP: rs28366003
rs28366003
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Compared with homozygous co</span>mmon allele carriers, heterozygous for the G varia</span>nt [odds ratio (OR) = 1.92, 95 % confidence interval (CI):1.28-2.81, p trend <0.01; the OR assuming a dominant model 1.93 (95 % CI: 1.29-2.89, (p dominant) <0.02) after adjustment for age, family history, smoking status, BMI, menarche, parity, menopausal status and use of contraceptive and menopausal hormones] had a significantly increased risk of breast cancer in Polish population, as well as women with haplotypes, including variant allele of rs28366003 SNP (OR = 1.58, CI: 0.41-6.33, p global = 0.03). 23053628 2014