MTHFR, methylenetetrahydrofolate reductase, 4524

N. diseases: 985; N. variants: 137
Disease: Alzheimer's Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801131
rs1801131
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.020 GeneticVariation BEFREE In AD, we observed a significant (p = 0.04) association with C alleles of rs1801131. 22015309 2012
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE Genetic analyses did not indicate a significant association between the MTHFR C677T mutation and A</span>D (C/T: 63.15% versus 39%, p=0.087). 23659764 2013
dbSNP: rs397507444
rs397507444
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.070 GeneticVariation BEFREE The MTHFR A1298C polymorphism is a possible risk factor for Alzheimer's disease. 23659764 2013
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE The MTHFR 677C>T polymorphism--especially the presence of one copy of the T allele--appears to confer a potential risk for the development of AD. 24223459 2013
dbSNP: rs1801133
rs1801133
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.050 GeneticVariation BEFREE We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD. 25359311 2015
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE The MTHFR C677T polymorphism may be a risk factor for AD in Asians, APOE ϵ4 carriers, and late-onset AD. 25486592 2015
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE Results of present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD. 26820674 2017
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE These reports were combined with related observational studies, and used to evaluate the effect of MTHFR C677T (rs1801133) on the risk for AD. 27031476 2016
dbSNP: rs1801133
rs1801133
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.050 GeneticVariation BEFREE These reports were combined with related observational studies, and used to evaluate the effect of MTHFR C677T (rs1801133) on the risk for AD. 27031476 2016
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE This report suggests the value of genotyping patients at the C677T functional variant when using plasma ApoE levels as a preclinical biomarker for Alzheimer's disease. 27380243 2016
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE <i>MTHFR</i> C677T TT and CT genotypes had significant associations with AD risk in all ra</span>cial populations (RR = 1.13, <i>p</i> = 0.0047; and RR = 1.12, <i>p</i> < 0.0001 respectively). 28085050 2017
dbSNP: rs397507444
rs397507444
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.070 GeneticVariation BEFREE This meta-analysis reveals that MTHFR A1298C polymorphism may not be associated with AD risk. 28281392 2017
dbSNP: rs1801131
rs1801131
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.020 GeneticVariation BEFREE Previous studies have investigated the association between MTHFR A1298C (rs1801131) polymorphism and susceptibility to Alzheimer's disease (AD). 28281392 2017
dbSNP: rs1217691063
rs1217691063
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0002395
Disease:
Alzheimer's Disease 		0.100 GeneticVariation BEFREE Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease. 28342207 2017