|
rs11466112
|
NGF;NGF-AS1
|
Hereditary Sensory Autonomic Neuropathy, Type 5
|
A |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
|
rs6330
|
NGF;NGF-AS1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
The self-ratable State-Trait Anxiety Inventory, which enables anxiety to be quantified as a comparatively stable personality trait was applied and a recently described non-synonymous NGF SNP (rs6330,c.104C > T,p.Ala35Val) was examined.
|
18763222 |
2008 |
|
rs6330
|
NGF;NGF-AS1
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
The self-ratable State-Trait Anxiety Inventory, which enables anxiety to be quantified as a comparatively stable personality trait was applied and a recently described non-synonymous NGF SNP (rs6330,c.104C > T,p.Ala35Val) was examined.
|
18763222 |
2008 |
|
rs11466112
|
NGF;NGF-AS1
|
Pain
|
|
0.030 |
GeneticVariation |
BEFREE |
Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF.
|
19038341 |
2009 |
|
rs11466112
|
NGF;NGF-AS1
|
Deep pain
|
|
0.010 |
GeneticVariation |
BEFREE |
We have previously identified a homozygous missense (R221W) mutation in the NGFB gene in patients with loss of deep pain perception.
|
19038341 |
2009 |
|
rs11466112
|
NGF;NGF-AS1
|
Pain
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |
|
rs11102930
|
NGF;NGF-AS1
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping data of 197 patients and 289 control subjects revealed significant association between NGF SNP rs11102930 and presence of IgAN.
|
21178826 |
2011 |
|
rs6330
|
NGF;NGF-AS1
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding the functional roles of neurotrophin polymorphisms as they relate to executive dysfunction, the NGF gene rs6330 might influence the inhibition task in Japanese patients with early-stage AD or A-MCI.
|
22301435 |
2011 |
|
rs6330
|
NGF;NGF-AS1
|
Executive dysfunction
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding the functional roles of neurotrophin polymorphisms as they relate to executive dysfunction, the NGF gene rs6330 might influence the inhibition task in Japanese patients with early-stage AD or A-MCI.
|
22301435 |
2011 |
|
rs6330
|
NGF;NGF-AS1
|
Presenile dementia
|
|
0.010 |
GeneticVariation |
BEFREE |
Among 200 outpatients with dementia and MCI whose NGF SNP rs6330 genotype was identified, those with A-MCI (n = 35) and early-stage AD (n = 67) were recruited and divided into three groups according to genotype (C/C: n = 58, C/T: n = 39, T/T: n = 5).
|
22301435 |
2011 |
|
rs6330
|
NGF;NGF-AS1
|
Dementia
|
|
0.010 |
GeneticVariation |
BEFREE |
Among 200 outpatients with dementia and MCI whose NGF SNP rs6330 genotype was identified, those with A-MCI (n = 35) and early-stage AD (n = 67) were recruited and divided into three groups according to genotype (C/C: n = 58, C/T: n = 39, T/T: n = 5).
|
22301435 |
2011 |
|
rs6330
|
NGF;NGF-AS1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
We report first evidence that children with one or more copies of the T allele of NGF rs6330 were significantly more likely to be free of their primary anxiety diagnosis at follow-up (OR = 0.60 (0.42-0.85), P = 0.005).
|
22832952 |
2012 |
|
rs6330
|
NGF;NGF-AS1
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
We report first evidence that children with one or more copies of the T allele of NGF rs6330 were significantly more likely to be free of their primary anxiety diagnosis at follow-up (OR = 0.60 (0.42-0.85), P = 0.005).
|
22832952 |
2012 |
|
rs11102930
|
NGF;NGF-AS1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, gene-gene interaction analysis revealed a significant epistatic interaction between MAPK (rs889312) and NGF (rs11102930) variants in asthma susceptibility.
|
22468730 |
2012 |
|
rs4076018
|
NGF;NGF-AS1
|
Intervertebral Disc Degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs4076018 SNP of NGFB was highly significant (p<.01) and rs2292657 SNP of GLI1 was significantly (p<.05) correlated to disc degeneration.
|
23792102 |
2013 |
|
rs6330
|
NGF;NGF-AS1
|
Diabetic Foot
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the other following polymorphisms was observed to be a potential risk factor of CKD in T2DM and DF population: rs6330, rs759853, rs1553005, rs1799983, rs1801133, rs1800469, rs8192678, rs11466112, rs121917832.
|
26579581 |
2015 |
|
rs6330
|
NGF;NGF-AS1
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the other following polymorphisms was observed to be a potential risk factor of CKD in T2DM and DF population: rs6330, rs759853, rs1553005, rs1799983, rs1801133, rs1800469, rs8192678, rs11466112, rs121917832.
|
26579581 |
2015 |
|
rs11102916
|
NGF;NGF-AS1
|
Diastolic blood pressure
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
rs11102916
|
NGF;NGF-AS1
|
Systolic Pressure
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
rs11466111
|
NGF;NGF-AS1
|
Diastolic blood pressure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
|
28135244 |
2017 |
|
rs6330
|
NGF;NGF-AS1
|
Anxiety state
|
|
0.010 |
GeneticVariation |
BEFREE |
In family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, interleukin ( IL1B) 1β) was associated with observed child distress at Bonferroni-corrected levels of significance ( p = .00013), while two approached significance for association with high state anxiety (rs6330 Nerve Growth Factor, Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic factor [ BDNF]).
|
28413930 |
2017 |
|
rs6330
|
NGF;NGF-AS1
|
Anxiety neurosis (finding)
|
|
0.010 |
GeneticVariation |
BEFREE |
In family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, interleukin ( IL1B) 1β) was associated with observed child distress at Bonferroni-corrected levels of significance ( p = .00013), while two approached significance for association with high state anxiety (rs6330 Nerve Growth Factor, Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic factor [ BDNF]).
|
28413930 |
2017 |
|
rs6330
|
NGF;NGF-AS1
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we evaluated the association of the functional polymorphisms in NGF (rs6330) and NGFR (rs2072446 and rs734194) genes with ischemic stroke in an Armenian population.
|
29499660 |
2018 |
|
rs6330
|
NGF;NGF-AS1
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation |
BEFREE |
The results obtained indicate that the minor allele of rs6330 (P <sub>corr</sub> = 2.4E-10) and rs2072446 (P <sub>corr</sub> = 0.02) are significantly overrepresented in stroke group, while the minor allele of rs734194 (P <sub>corr</sub> = 8.5E-10) was underrepresented in diseased subjects.
|
29499660 |
2018 |
|
rs769190598
|
NGF;NGF-AS1
|
Hereditary Sensory Autonomic Neuropathy, Type 5
|
|
0.010 |
GeneticVariation |
BEFREE |
Generation of the human induced pluripotent stem cell line UKWNLi002-A from dermal fibroblasts of a woman with a heterozygous c.608 C>T (p.Thr203Met) mutation in exon 3 of the nerve growth factor gene potentially associated with hereditary sensory and autonomic neuropathy type 5.
|
30384131 |
2018 |