|
rs1718119
|
P2RX7;LOC105370032
|
PERIODONTITIS, LOCALIZED AGGRESSIVE
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with localized aggressive periodontitis was observed with rs1718119 A (Thr) allele (P = 0.0063, odds ratio = 1.904) and with a haplotype containing this allele (P = 0.0075).
|
31292966 |
2020 |
|
rs1621388
|
P2RX7;LOC105370032
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated sex-specific genetic associations between variants of P2RX7 (rs1621388 and rs2230912) in 756 patients with bipolar disorder and 787 control patients matched on age, sex, and ancestry.
|
30445384 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying rs1718119 allele A had a reduced risk (OR 0.69; 95% CI: 0.45-1.06).Genetic polymorphisms in IL17A, TLR4 and P2RX7 genes were significantly associated with altered risks for COPD.
|
29704988 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
However, dimensional analyses showed significant associations of the HADS depression severity scores with Gln460Arg (rs2230912) and Ala348Thr (rs1718119) in the depressed and diabetic patient groups.
|
30664971 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Chronic Q Fever
|
|
0.010 |
GeneticVariation |
BEFREE |
RAB7A (rs13081864) and P2RX7 (rs3751143) are associated with the development of chronic Q fever, whereas RAB5A (rs8682), P2RX7 (rs1718119), MAP1LC3A (rs1040747) and ATG5 (rs2245214) may have protective effects.
|
30616015 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
However, dimensional analyses showed significant associations of the HADS depression severity scores with Gln460Arg (rs2230912) and Ala348Thr (rs1718119) in the depressed and diabetic patient groups.
|
30664971 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs1718119
|
P2RX7;LOC105370032
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
However, dimensional analyses showed significant associations of the HADS depression severity scores with Gln460Arg (rs2230912) and Ala348Thr (rs1718119) in the depressed and diabetic patient groups.
|
30664971 |
2019 |
|
rs1718125
|
P2RX7;LOC105370032
|
Pain, Postoperative
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
|
30762755 |
2019 |
|
rs1718125
|
P2RX7;LOC105370032
|
Agnosia for Pain
|
|
0.010 |
GeneticVariation |
BEFREE |
Correlation of P2RX7 gene rs1718125 polymorphism with postoperative fentanyl analgesia in patients with lung cancer.
|
30762755 |
2019 |
|
rs1718125
|
P2RX7;LOC105370032
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
|
30762755 |
2019 |
|
rs1718125
|
P2RX7;LOC105370032
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
|
30762755 |
2019 |
|
rs1718125
|
P2RX7;LOC105370032
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
|
30762755 |
2019 |
|
rs2230911
|
P2RX7;LOC105370032
|
Osteoporosis, Postmenopausal
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b><i>P2X7R</i> rs2230911 was found to be associated with serum total cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein, and BMD at the lumbar spine and hip in OP patients (<i>p</i> < 0.05).
|
31079509 |
2019 |
|
rs2230911
|
P2RX7;LOC105370032
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs28360451
|
P2RX7;LOC105370032
|
Hypertrophic Cardiomyopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one non-synonymous mutation (p. Glu186Lys or E186K) in exon 6 of P2X7 gene segregated in HCM-affected individuals which was absent in unaffected family members and 100 clinically evaluated controls.
|
31152337 |
2019 |
|
rs3751143
|
P2RX7;LOC105370032
|
Chronic Q Fever
|
|
0.010 |
GeneticVariation |
BEFREE |
RAB7A (rs13081864) and P2RX7 (rs3751143) are associated with the development of chronic Q fever, whereas RAB5A (rs8682), P2RX7 (rs1718119), MAP1LC3A (rs1040747) and ATG5 (rs2245214) may have protective effects.
|
30616015 |
2019 |
|
rs3751143
|
P2RX7;LOC105370032
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs3751143
|
P2RX7;LOC105370032
|
Osteoporosis, Postmenopausal
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>P2X7R</i> rs3751143 was shown to be associated with serum TG and hip BMD in OP patients (<i>p</i> < 0.05).
|
31079509 |
2019 |
|
rs7958311
|
P2RX7;LOC105370032
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic variation of rs7958311 SNP in <i>P2X7R</i> gene may have a protective effect on AS susceptibility in females and is associated with disease activity in male patients.
|
30992418 |
2019 |
|
rs2393799
|
P2RX7;LOC105370032
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with obesity or overweight was observed for the other three P2X7R polymorphisms (rs2393799, rs7958311, and rs3751143).
|
29088017 |
2018 |
|
rs3751143
|
P2RX7;LOC105370032
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with obesity or overweight was observed for the other three P2X7R polymorphisms (rs2393799, rs7958311, and rs3751143).
|
29088017 |
2018 |
|
rs1653624
|
P2RX7;LOC105370032
|
Hyperuricemia
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-1β concentrations in supernatants after MSU + ATP stimulation were significantly higher in gouty patients than in the hyperuricemia group [(131.08 ± 176.11) pg/ml vs. (50.84 ± 86.10) pg/ml]; Patients (including gout and hyperuricemia) carrying the susceptibility genotype AA or AT of rs1653624 exhibited significantly higher concentrations of IL-1β than patients carrying the non-susceptibility genotype TT [(104.20 ± 164.25) pg/ml vs. (21.90 ± 12.14) pg/ml]; However, no differences were found with MSU stimulation alone.
|
28797095 |
2017 |
|
rs1718119
|
P2RX7;LOC105370032
|
Active tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A of rs1718119 was related to a reduced risk for all active tuberculosis (OR for each additional allele A: 0.81, 95% CI: 0.69-0.94) and sputum smear-positive cases (OR for each additional allele A: 0.78, 95% CI: 0.66-0.93).
|
28495473 |
2017 |
|
rs1718119
|
P2RX7;LOC105370032
|
Osteoporosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that rs3751143 was associated with OP; in particular, carriers of the C allele and CC/(AC + CC) genotypes were at a higher risk of OP, but no significant association of rs2230911, rs7958311, rs1718119, and rs2393799 with OP risk was observed.
|
28497417 |
2017 |