REEP2, receptor accessory protein 2, 51308

N. diseases: 26; N. variants: 5
Disease: Henoch-Schoenlein Purpura ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs483352923
rs483352923
Entrez Id: 51308
Gene Symbol: REEP2
REEP2
CUI: C0034152
Disease:
Henoch-Schoenlein Purpura 		0.010 GeneticVariation BEFREE With a combination of whole-genome mapping and exome sequencing, we identified three mutations in REEP2 in two families with HSP: a missense variant (c.107T>A [p.Val36Glu]) that segregated in the heterozygous state in a family with autosomal-dominant inheritance and a missense change (c.215T>A [p.Phe72Tyr]) that segregated in trans with a splice site mutation (c.105+3G>T) in a family with autosomal-recessive transmission. 24388663 2014