rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
0.740
GeneticVariation
BEFREE
All mutations were mutually exclusive, apart from one basal-like breast tumour which harboured mutations in both MET (p.T992I) and PIK3CA (p.H1047R ).
24318467
2014
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
18676830
2008
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
18676830
2008
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974
2008
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974
2008
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
0.740
GeneticVariation
BEFREE
In addition, the combined treatment of DSF and LY294002 significantly inhibited the growth of the breast tumor xenograft in nude mice induced by MDA-MB-231 cells expressing mutant PIK3CA-H1047R and PIK3CA-E545K, whereas neither DSF nor LY294002 alone could significantly retard tumor growth.
20424113
2010
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
0.740
GeneticVariation
BEFREE
Our results suggest that the PIK3CA H1047R oncogene targets a multipotent progenitor cell and, furthermore, show that this model recapitulates features of human breast tumors with PIK3CA H1047R .
21482677
2011
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
22162589
2012
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
22162589
2012
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.
22162582
2012
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.
22162582
2012
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
15805248
2005
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
15805248
2005
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058
2010
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058
2010
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
T
0.740
CausalMutation
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
G
0.740
CausalMutation
CLINVAR
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
21558396
2011
rs121913279
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Mammary Neoplasms
0.740
GeneticVariation
BEFREE
We found that activation of the latent Pik3ca(H1047R ) allele resulted in breast tumors with multiple histological types.
22370636
2013