TET2, tet methylcytosine dioxygenase 2, 54790

N. diseases: 362; N. variants: 47
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12498609
rs12498609
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C3463824
Disease:
MYELODYSPLASTIC SYNDROME 		0.010 GeneticVariation BEFREE TET2 rs2454206, TET2 rs12498609 and ASXL1 rs3746609 single nucleotide polymorphisms in patients with myelodysplastic syndromes. 30454965 2019
dbSNP: rs2454206
rs2454206
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C3463824
Disease:
MYELODYSPLASTIC SYNDROME 		0.010 GeneticVariation BEFREE We concluded that People with TET rs2454206 G/A genotype, TET2rs12498609 G/C genotype or ASXL1rs3746609 A/G genotype were related to lower prevalence of MDS. 30454965 2019
dbSNP: rs1221877686
rs1221877686
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE While there was a trend toward an earlier age at diagnosis, overall the clinicopathologic features of PCa were not significantly different in G84E carriers and non-carriers. 29181843 2018
dbSNP: rs1221877686
rs1221877686
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0600139
Disease:
Prostate carcinoma 		0.010 GeneticVariation BEFREE While there was a trend toward an earlier age at diagnosis, overall the clinicopathologic features of PCa were not significantly different in G84E carriers and non-carriers. 29181843 2018
dbSNP: rs2454206
rs2454206
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0220621
Disease:
Childhood Acute Myeloid Leukemia 		0.010 GeneticVariation BEFREE No difference in TET2 expression levels in AML with TET2 SNP rs2454206<sup>AA</sup> and TET2 SNP rs2454206<sup>AG/GG</sup> was detected, indicating that TET2 SNP rs2454206 status does not affect TET2 expression in pediatric AML. 29664232 2018
dbSNP: rs2454206
rs2454206
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.010 GeneticVariation BEFREE No difference in TET2 expression levels in AML with TET2 SNP rs2454206<sup>AA</sup> and TET2 SNP rs2454206<sup>AG/GG</sup> was detected, indicating that TET2 SNP rs2454206 status does not affect TET2 expression in pediatric AML. 29664232 2018
dbSNP: rs72963007
rs72963007
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0023493
Disease:
Adult T-Cell Lymphoma/Leukemia 		0.010 GeneticVariation BEFREE Strikingly, 9 of the 14 patients showed the same variation (SNP rs72963007), whose frequency in ATLL patients was significantly higher than that of an ethnically matched control population (13% vs. 5%). 28881727 2017
dbSNP: rs3733609
rs3733609
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0027022
Disease:
Myeloproliferative disease 		0.010 GeneticVariation BEFREE A TET2 rs3733609 C/T genotype is associated with predisposition to the myeloproliferative neoplasms harboring JAK2(V617F) and confers a proliferative potential on erythroid lineages. 26843622 2016
dbSNP: rs3733609
rs3733609
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C1292778
Disease:
Chronic myeloproliferative disorder 		0.010 GeneticVariation BEFREE Altogether, we found a novel hereditary susceptible factor-TET2 rs3733609 C/T variant for the development of MPN, suggesting the variant may be partially responsible for the pathogenesis and accumulation of MPN. 26843622 2016
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0024143
Disease:
Lupus Nephritis 		0.010 GeneticVariation BEFREE Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1). 26509176 2015
dbSNP: rs2454206
rs2454206
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease 		0.010 GeneticVariation BEFREE The p.Ile1762Val substitution (TET2-rs2454206) was associated with liver PPARGC1A-methylation and transcriptional levels, and Type 2 diabetes.Our results suggest that 5-hmC might be involved in the pathogenesis of NAFLD by regulating liver mitochondrial biogenesis and PPARGC1A expression. 26356709 2015
dbSNP: rs2454206
rs2454206
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE The p.Ile1762Val substitution (TET2-rs2454206) was associated with liver PPARGC1A-methylation and transcriptional levels, and Type 2 diabetes.Our results suggest that 5-hmC might be involved in the pathogenesis of NAFLD by regulating liver mitochondrial biogenesis and PPARGC1A expression. 26356709 2015
dbSNP: rs1368725108
rs1368725108
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0796466
Disease:
Refractory cytopenia with multilineage dysplasia 		0.010 GeneticVariation BEFREE We report a novel g.95805C>T, nonsense TET2 mutation, leading to a premature stop codon (p.Gln913*), in an adult patient with refractory cytopenia with multilineage dysplasia. 24301955 2013
dbSNP: rs10010325
rs10010325
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0021704
Disease:
Intelligence 		A 0.700 GeneticVariation GWASCAT A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. 29326435 2019
dbSNP: rs11726786
rs11726786
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0021704
Disease:
Intelligence 		T 0.700 GeneticVariation GWASCAT A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. 29326435 2019
dbSNP: rs1391440
rs1391440
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0021704
Disease:
Intelligence 		C 0.700 GeneticVariation GWASCAT A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. 29326435 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0007102
Disease:
Malignant tumor of colon 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0009402
Disease:
Colorectal Carcinoma 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C3554460
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C1302401
Disease:
Adenoma of large intestine 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C0346629
Disease:
Malignant neoplasm of large intestine 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C2677123
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs1391441
rs1391441
Entrez Id: 54790;104384744
Gene Symbol: TET2;TET2-AS1
TET2;TET2-AS1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019