PBRM1, polybromo 1, 55193

N. diseases: 105; N. variants: 54
Disease: Major Depressive Disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2251219
rs2251219
Entrez Id: 55193;440957
Gene Symbol: PBRM1;SMIM4
PBRM1;SMIM4
CUI: C1269683
Disease:
Major Depressive Disorder 		0.710 GeneticVariation GWASDB A mega-analysis of genome-wide association studies for major depressive disorder. 22472876 2013
dbSNP: rs2251219
rs2251219
Entrez Id: 55193;440957
Gene Symbol: PBRM1;SMIM4
PBRM1;SMIM4
CUI: C1269683
Disease:
Major Depressive Disorder 		0.710 GeneticVariation BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012