IKZF4, IKAROS family zinc finger 4, 64375

N. diseases: 9; N. variants: 7
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C0004364
Disease:
Autoimmune Diseases 		0.010 GeneticVariation BEFREE The C allele of rs2456973 at 12q13.2 was observed to be significantly associated with vitiligo-associated immune-related diseases (autoimmune diseases and allergic diseases) (P = 0.0028, odds ratio (OR) = 1.27). 25952005 2015
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C1847835
Disease:
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) 		0.010 GeneticVariation BEFREE The C allele of rs2456973 at 12q13.2 was observed to be significantly associated with vitiligo-associated immune-related diseases (autoimmune diseases and allergic diseases) (P = 0.0028, odds ratio (OR) = 1.27). 25952005 2015
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C1847835
Disease:
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) 		0.010 GeneticVariation BEFREE We identified three susceptibility loci, 12q13.2 (rs10876864, P(combined)=8.07 × 10(-12), odds ratio (OR)=1.18), 11q23.3 (rs638893, P(combined)=2.47 × 10(-9), OR=1.22), and 10q22.1 (rs1417210, P(combined)=1.83 × 10(-8), OR=0.88), and confirmed three previously reported loci for vitiligo, 3q28 (rs9851967, P(combined)=8.57 × 10(-8), OR=0.88), 10p15.1 (rs3134883, P(combined)=1.01 × 10(-5), OR=1.11), and 22q12.3 (rs2051582, P(combined)=2.12 × 10(-5), OR=1.14), in the Chinese Han population. 22951725 2013
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C0021704
Disease:
Intelligence 		A 0.700 GeneticVariation GWASCAT A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. 29326435 2019
dbSNP: rs772921
rs772921
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0037369
Disease:
Smoking 		T 0.700 GeneticVariation GWASCAT Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. 30643258 2019
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C1527304
Disease:
Allergic Reaction 		0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
dbSNP: rs1702877
rs1702877
Entrez Id: 64375;105369780
Gene Symbol: IKZF4;LOC105369780
IKZF4;LOC105369780
CUI: C0021704
Disease:
Intelligence 		T 0.700 GeneticVariation GWASCAT Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 29844566 2018
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C1527304
Disease:
Allergic Reaction 		G 0.700 GeneticVariation GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C0021704
Disease:
Intelligence 		0.700 GeneticVariation GWASCAT Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. 29186694 2017
dbSNP: rs2017445
rs2017445
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0042900
Disease:
Vitiligo 		A 0.700 GeneticVariation GWASCAT Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. 27723757 2016
dbSNP: rs137948794
rs137948794
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C1519383
Disease:
Smoking Behaviors 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs137948794
rs137948794
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0037369
Disease:
Smoking 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0042900
Disease:
Vitiligo 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C1272321
Disease:
Autoantibody measurement 		T 0.700 GeneticVariation GWASDB Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393 2011
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. 21804548 2011
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASDB Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. 21804548 2011
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0002171
Disease:
Alopecia Areata 		C 0.800 GeneticVariation GWASDB Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. 20596022 2010
dbSNP: rs1701704
rs1701704
Entrez Id: 64375;105369781
Gene Symbol: IKZF4;LOC105369781
IKZF4;LOC105369781
CUI: C0002171
Disease:
Alopecia Areata 		C 0.800 GeneticVariation GWASCAT Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. 20596022 2010
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C0042900
Disease:
Vitiligo 		0.810 GeneticVariation BEFREE The C allele of rs2456973 at 12q13.2 was observed to be significantly associated with vitiligo-associated immune-related diseases (autoimmune diseases and allergic diseases) (P = 0.0028, odds ratio (OR) = 1.27). 25952005 2015
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C0042900
Disease:
Vitiligo 		G 0.810 GeneticVariation GWASDB Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. 22951725 2013
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C0042900
Disease:
Vitiligo 		0.810 GeneticVariation BEFREE We identified three susceptibility loci, 12q13.2 (rs10876864, P(combined)=8.07 × 10(-12), odds ratio (OR)=1.18), 11q23.3 (rs638893, P(combined)=2.47 × 10(-9), OR=1.22), and 10q22.1 (rs1417210, P(combined)=1.83 × 10(-8), OR=0.88), and confirmed three previously reported loci for vitiligo, 3q28 (rs9851967, P(combined)=8.57 × 10(-8), OR=0.88), 10p15.1 (rs3134883, P(combined)=1.01 × 10(-5), OR=1.11), and 22q12.3 (rs2051582, P(combined)=2.12 × 10(-5), OR=1.14), in the Chinese Han population. 22951725 2013
dbSNP: rs10876864
rs10876864
Entrez Id: 64375
Gene Symbol: IKZF4
IKZF4
CUI: C0042900
Disease:
Vitiligo 		G 0.810 GeneticVariation GWASCAT Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. 22951725 2013
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C0042900
Disease:
Vitiligo 		C 0.810 GeneticVariation GWASCAT Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
dbSNP: rs2456973
rs2456973
Entrez Id: 64375;105369780;105369781
Gene Symbol: IKZF4;LOC105369780;LOC105369781
IKZF4;LOC105369780;LOC105369781
CUI: C0042900
Disease:
Vitiligo 		C 0.810 GeneticVariation GWASDB Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012