SHMT1, serine hydroxymethyltransferase 1, 6470

N. diseases: 106; N. variants: 12
Disease: Lymphoma, Non-Hodgkin ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1979277
rs1979277
Entrez Id: 6470
Gene Symbol: SHMT1
SHMT1
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin 		0.020 GeneticVariation BEFREE The polymorphisms examined and haplotypes generated included thymidylate synthase (TYMS 28-bp triple repeat [3R]-->double repeat [2R], 1494del6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the largest and most comprehensive to date to evaluate associations between genetic polymorphisms in folatemetabolizing genes and NHL risk. 15198953 2004
dbSNP: rs1979277
rs1979277
Entrez Id: 6470
Gene Symbol: SHMT1
SHMT1
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin 		0.020 GeneticVariation BEFREE SHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies. 26666829 2015