NCF1, neutrophil cytosolic factor 1, 653361

N. diseases: 170; N. variants: 11
Disease: Autoimmune Diseases ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs201802880
rs201802880
Entrez Id: 653361
Gene Symbol: NCF1
NCF1
CUI: C0004364
Disease:
Autoimmune Diseases 		0.010 GeneticVariation BEFREE We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production, predisposes to SLE (odds ratio (OR) = 3.47 in Asians (P<sub>meta</sub> = 3.1 × 10<sup>-104</sup>), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjögren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans). 28135245 2017