SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Disease: Parkinson Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3822086
rs3822086
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.730 GeneticVariation BEFREE In addition, rs3822086 polymorphism was found to be related to PD in the allelic (OR = 1.249, 95% CI: 1.099-1.419, p = 0.001), homozygous (OR = 1.479, 95% CI: 1.142-1.915, p = 0.003), heterozygous (OR = 1.292, 95% CI: 1.033-1.615, p = 0.025) and dominant (OR = 1.331, 95% CI: 1.030-1.719, p = 0.029) models. 31325583 2019
dbSNP: rs3822086
rs3822086
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.730 GeneticVariation BEFREE Our findings demonstrate that the SNCA rs3822086 C>T polymorphism correlates with increased susceptibility to PD among the Chinese Han population. 26203864 2015
dbSNP: rs3822086
rs3822086
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.730 GeneticVariation BEFREE Our results suggest that the rs3822086 (C) allele and rs11931074 (G) allele in SNCA decrease the risk for PD, and SNCA rs11931074 may affect frontal lobe dysfunction of MSA in the Chinese population. 26208350 2015
dbSNP: rs3822086
rs3822086
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.730 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs3822086
rs3822086
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.730 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011