SORL1, sortilin related receptor 1, 6653

N. diseases: 103; N. variants: 29
Disease: Alzheimer's Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3824968
rs3824968
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0002395
Disease:
Alzheimer's Disease 		0.040 GeneticVariation BEFREE Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan. 26996954 2016
dbSNP: rs3824968
rs3824968
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0002395
Disease:
Alzheimer's Disease 		0.040 GeneticVariation BEFREE Significant associations between CSF Aβ(1-42) levels and the SORL1 SNPs 23 (rs3824968) and 24 (rs2282649) were detected in the AD group. 21997402 2011
dbSNP: rs3824968
rs3824968
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0002395
Disease:
Alzheimer's Disease 		0.040 GeneticVariation BEFREE In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias. 19368828 2009
dbSNP: rs3824968
rs3824968
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0002395
Disease:
Alzheimer's Disease 		0.040 GeneticVariation BEFREE We conducted haloptype analysis involving two genetic clusters of SORL1 in AD and controls among Han Chinese. rs3824968 (SNP 23) was associated with an increased risk of AD, and there was a trend towards association for rs1699102 (SNP 22) and rs2282649 (SNP 24). 18063222 2009