Disease: melanoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		0.720 GeneticVariation BEFREE Among 41 response-evaluable patients, 2 (5 %) patients with cutaneous melanoma (one with BRAF L597R mutant melanoma) had partial responses. 27650277 2017
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. 23715574 2013
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300 2013
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. 23715574 2013
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300 2013
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. 22805292 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. 22805292 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. 22798288 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. 22798288 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		0.720 GeneticVariation BEFREE This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. 22798288 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091 2012
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. 21483012 2011
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. 21483012 2011
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210 2009
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210 2009
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912 2008
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912 2008
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002
dbSNP: rs121913366
rs121913366
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0025202
Disease:
melanoma 		C 0.720 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002