rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Use of aromatase inhibitors in large cell calcifying sertoli cell tumors: effects on gynecomastia, growth velocity, and bone age.
25226294
2014
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance.
23240097
2013
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.
23718779
2013
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.
23399955
2013
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.
21411391
2011
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
21189378
2011
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Alu-mediated genomic deletion of the serine/threonine protein kinase 11 (STK11) gene in Peutz-Jeghers syndrome.
20435009
2010
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
19892943
2009
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome.
16582077
2006
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus.
17026623
2006
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
15987703
2005
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.
16287113
2005
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
14976552
2004
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
12865922
2003
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
14517248
2003
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.
12372054
2002
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
A
0.800
CausalMutation
CLINVAR
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
10408777
1999
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
10408777
1999
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
9428765
1998
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.
9425897
1998
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
9760200
1998
rs121913315
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
Peutz-Jeghers Syndrome
0.800
GeneticVariation
UNIPROT
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
9837816
1998