TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Low Tension Glaucoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7037117
rs7037117
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0152136
Disease:
Low Tension Glaucoma 		0.010 GeneticVariation BEFREE With regard to genotypic diversity, individuals with the minor allele of six SNPs (rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, and rs7037117</span>) had a 1.47- to 1.65-fold increased risk of NTG. rs7037117, located in the 3'-untranslated region of TLR4, was most strongly associated with NTG, and when incorporated into a haplotype with rs10759930, the strongest association was detected (P = 0.0038, P(c) = 0.0095). 18586872 2008