|
rs1061622
|
TNFRSF1B
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation |
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
rs677844
|
TNFRSF1B
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we identified two potentially functional SNPs (IKBKAP rs4978754 C > T and TNFRSF1B rs677844 T > C) to be associated with survival of patients with NSCLC.
|
30989732 |
2019 |
|
rs677844
|
TNFRSF1B
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The Cancer Genome Atlas (TCGA)-based expression quantitative trait loci analysis showed that IKBKAP rs4978754 and TNFRSF1B rs677844 genotypes were significantly associated with their corresponding mRNA expression levels in lung cancer tissues in a recessive model (P = 0.035 and 0.045, respectively).
|
30989732 |
2019 |
|
rs677844
|
TNFRSF1B
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The Cancer Genome Atlas (TCGA)-based expression quantitative trait loci analysis showed that IKBKAP rs4978754 and TNFRSF1B rs677844 genotypes were significantly associated with their corresponding mRNA expression levels in lung cancer tissues in a recessive model (P = 0.035 and 0.045, respectively).
|
30989732 |
2019 |
|
rs677844
|
TNFRSF1B
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The Cancer Genome Atlas (TCGA)-based expression quantitative trait loci analysis showed that IKBKAP rs4978754 and TNFRSF1B rs677844 genotypes were significantly associated with their corresponding mRNA expression levels in lung cancer tissues in a recessive model (P = 0.035 and 0.045, respectively).
|
30989732 |
2019 |
|
rs1061622
|
TNFRSF1B
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
rs1061622
|
TNFRSF1B
|
Liver diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses.
|
29915336 |
2018 |
|
rs1061622
|
TNFRSF1B
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our case-control study (401 patients and 657 controls) revealed that the genetic variants of rs3397, rs1061622, and rs1061624 in the <i>TNFR2</i> gene are associated with a higher risk of developing schizophrenia and more severe course in men.
|
30254506 |
2018 |
|
rs1061622
|
TNFRSF1B
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Only rs1061622 was significantly associated with long-term efficacy of etanercept: the TG genotype of rs1061622 worsened ASAS20 and ASAS40 responses at 12 months (P = .021 and .041, respectively).The results suggest that TNFRSF1A and TNFRSF1B polymorphisms were associated with susceptibility, severity, and the long-term therapeutic efficacy of etanercept of patients with AS.
|
30075559 |
2018 |
|
rs1061622
|
TNFRSF1B
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
rs1061622
|
TNFRSF1B
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
rs1061624
|
TNFRSF1B
|
Paranoid Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the association of the three single nucleotide polymorphisms (rs3397, rs1061622, and rs1061624) in <i>TNFR2</i> gene with a predisposition to and psychopathology of paranoid schizophrenia in Caucasian population.
|
30254506 |
2018 |
|
rs1061624
|
TNFRSF1B
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation |
BEFREE |
Our retrospective study suggests that the TNFR2 rs1061624 polymorphism is associated with HBV-related CHB, LC, and HCC in Chinese population, particularly in males.
|
29915336 |
2018 |
|
rs1061624
|
TNFRSF1B
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our case-control study (401 patients and 657 controls) revealed that the genetic variants of rs3397, rs1061622, and rs1061624 in the <i>TNFR2</i> gene are associated with a higher risk of developing schizophrenia and more severe course in men.
|
30254506 |
2018 |
|
rs142907823
|
TNFRSF1B
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs781754593
|
TNFRSF1B
|
Glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we provide evidence that preventing phosphorylation of p75(NTR) on S303 by pharmacological inhibition of PKA, or by a mutational strategy (S303G), cripples p75(NTR)-mediated glioma invasion resulting in serine phosphorylation within the C-terminal PDZ-binding motif (SPV) of p75(NTR).
|
26119933 |
2016 |
|
rs1061622
|
TNFRSF1B
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
rs1061622
|
TNFRSF1B
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
rs1061622
|
TNFRSF1B
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
rs1061624
|
TNFRSF1B
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, in rs1061624 of TNFRSF1B gene, AG genotype (OR=0.566; 95% CI= 0.362, 0.885) and AG/GG genotype (OR=0.638; 95% CI=0.420, 0.971) were significantly associated with a decreased risk of rectal cancer, respectively.
|
24762198 |
2014 |
|
rs1061624
|
TNFRSF1B
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
rs1061624
|
TNFRSF1B
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
rs1061622
|
TNFRSF1B
|
Congestive heart failure
|
|
0.010 |
GeneticVariation |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
rs1061622
|
TNFRSF1B
|
Heart failure
|
|
0.010 |
GeneticVariation |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
rs1061622
|
TNFRSF1B
|
Refractory Neutropenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase- -C1562T, and TNF receptor two M196R (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race.
|
21627550 |
2012 |