XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Disease: Head and Neck Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs25489
rs25489
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C3887461
Disease:
Head and Neck Carcinoma 		0.030 GeneticVariation BEFREE The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. 24497981 2014
dbSNP: rs25489
rs25489
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C3887461
Disease:
Head and Neck Carcinoma 		0.030 GeneticVariation BEFREE A comprehensive literature search was conducted to identify all case-control studies of the XRCC1 Arg194Trp and Arg280His polymorphisms in head and neck cancer. 25062722 2014
dbSNP: rs25489
rs25489
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C3887461
Disease:
Head and Neck Carcinoma 		0.030 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility. 24086310 2013