ADAM33, ADAM metallopeptidase domain 33, 80332

N. diseases: 49; N. variants: 22
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2280090
rs2280090
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C1260881
Disease:
Allergic bronchitis
0.010 GeneticVariation BEFREE Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)). 27624002 2016
dbSNP: rs3918396
rs3918396
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C1260881
Disease:
Allergic bronchitis
0.010 GeneticVariation BEFREE Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)). 27624002 2016
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE In the total cohort, the rs511898 A, rs528557 C, and rs2280090 A alleles increased the risk to develop asthma (+BHR). 19236319 2009
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE Of the 8 SNPs genotyped, only S2[rs528557] showed significant association with asthma (Allele p = 0.0189, Genotype p = 0.021). 26666372 2016
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE Two-SNP haplotype analysis at the SNPs rs528557/S2 and rs598418 revealed a significant association with asthma. 19317339 2008
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE The ADAM33 rs528557/S2 SNP was found to be associated with asthma according to the additive and dominant models. 31586488 2019
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE Thus, the ADAM33 rs528557 C>G polymorphism may be utilized </span>as a biomarker for early diagnosis of asthma. 25068505 2014
dbSNP: rs528557
rs528557
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.060 GeneticVariation BEFREE Smoking may modify the associations between SNPs rs628977 and rs528557 and asthma. 22583515 2012
dbSNP: rs2280090
rs2280090
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE Haplotype analysis showed that rs2280090 and rs2280091 were associated with asthma in the patient group. 31719298 2019
dbSNP: rs2280090
rs2280090
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. 22851202 2012
dbSNP: rs2280090
rs2280090
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE In the total cohort, the rs511898 A, rs528557 C, and rs2280090 A alleles increased the risk to develop asthma (+BHR). 19236319 2009
dbSNP: rs2280091
rs2280091
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE Haplotype analysis showed that rs2280090 and rs2280091 were associated with asthma in the patient group. 31719298 2019
dbSNP: rs2280091
rs2280091
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. 22851202 2012
dbSNP: rs2280091
rs2280091
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.030 GeneticVariation BEFREE Significant associations with asthma were found for the SNPs T1 (Met764Thr), T2 (Pro774Ser), S2 and V-3 (with the lowest P-value for T1, P = 0.0015; OR 0.63). 16839403 2006
dbSNP: rs2787094
rs2787094
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. 25730038 2015
dbSNP: rs2787094
rs2787094
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE As rs44707 and rs2787094 are associated with asthma</span> and a distinctive palm pattern, the data suggest that ADAM33 polymorphisms are correlated with asthma and may be the underlying genetic basis of the association between asthma and palm dermatoglyphic patterns. 24141861 2013
dbSNP: rs44707
rs44707
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE Differences in allele frequencies at the SNPs rs528557/S2, rs598418 and rs44707/ST+4 in asthmatics were statistically significant compared to controls. 19317339 2008
dbSNP: rs44707
rs44707
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE As rs44707 and rs2787094 are associated with asthma and a distinctive palm pattern, the data suggest that ADAM33 polymorphisms are correlated with asthma and may be the underlying genetic basis of the association between asthma and palm dermatoglyphic patterns. 24141861 2013
dbSNP: rs511898
rs511898
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE In the total cohort, the rs511898 A, rs528557 C, and rs2280090 A alleles increased the risk to develop asthma (+BHR). 19236319 2009
dbSNP: rs511898
rs511898
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE <i>ADAM33</i> gene polymorphisms at positions T+1 (rs2280091), T1 (rs3918396), S1 (rs2280089), and F+1 (rs511898) were examined in 150 patients with asthma and 149 age- and sex-matched healthy controls with a PCR-RFLP method. 30186568 2018
dbSNP: rs678881
rs678881
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE Based on the results, five SNPs, rs44707 (codominant model, P=0.031; log‑additive model, P=0.0084), rs2787094 (overdominant model, P=0.049), rs678881 (codominant model, P=0.028; overdominant model, P=0.0083), rs677044 (codominant model, P=0.013; log‑additive model, P=0.0033) and rs512625 (dominant model, P=0.033), were associated with asthma in this population. 24141861 2013
dbSNP: rs678881
rs678881
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.020 GeneticVariation BEFREE Association intensity of the polymorphisms with the disease risk was assessed by odds ratio (OR) and 95% confidence interval (95%CI).The frequency of rs678881 GA genotype was obviously higher in cases than in controls (P = .03) and the carriage of this genotype conferred higher risk of asthma among children than GG genotype (OR = 2.03, 95%CI = 1.05-3.91). 31626088 2019
dbSNP: rs1259512299
rs1259512299
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q - 1A/G) of the ADAM33 gene may be the causal variants in ARA disease. 18752037 2009
dbSNP: rs2280089
rs2280089
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children. 31626088 2019
dbSNP: rs2853209
rs2853209
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children. 31626088 2019