DNAH11, dynein axonemal heavy chain 11, 8701

N. diseases: 110; N. variants: 109
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2285947
rs2285947
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus 		0.010 GeneticVariation BEFREE This study demonstrated that the polymorphisms rs2494938 at 6p21.1 and rs2285947 at 7p15.3 may serve as independent prognostic biomarkers for ESCC, implying the potential biological role of their related genes (LRFN2 and DNAH11) in the process of ESCC development. 31053115 2019
dbSNP: rs2285947
rs2285947
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0278996
Disease:
Malignant Head and Neck Neoplasm 		0.010 GeneticVariation BEFREE However, no significant association was observed between rs2285947 at 7p15.3 and HNC risk. 25524939 2015
dbSNP: rs2285947
rs2285947
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C3887461
Disease:
Head and Neck Carcinoma 		0.010 GeneticVariation BEFREE However, no significant association was observed between rs2285947 at 7p15.3 and HNC risk. 25524939 2015
dbSNP: rs4487645
rs4487645
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0026470
Disease:
Monoclonal Gammopathy of Undetermined Significance 		0.010 GeneticVariation BEFREE Each SNP independently influenced MGUS risk with statistically significant associations (P < .02) for rs1052501, rs2285803, rs4487645, and rs4273077. 24449210 2014
dbSNP: rs2285947
rs2285947
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE In combined samples of GWAS and replication stages, the minor alleles of rs2494938 and rs2285947 were significantly associated with an increased risk of the cancers (odds ratio [OR] = 1.15, 95% confidence interval [CI], 1.10-1.19 and OR = 1.17, 95% CI, 1.12-1.21), with the p values being 1.20 × 10(-12) and 1.26 × 10(-16), respectively, which are at a genome-wide significance level. 23103227 2012
dbSNP: rs66476925
rs66476925
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		C 0.700 GeneticVariation GWASCAT Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 30670697 2019
dbSNP: rs66476925
rs66476925
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		C 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs66476925
rs66476925
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C0001948
Disease:
Alcohol consumption 		C 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs10499535
rs10499535
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs12670798
rs12670798
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs2030672
rs2030672
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0596887
Disease:
mathematical ability 		G 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs2285942
rs2285942
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs55649657
rs55649657
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs56130071
rs56130071
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C1445957
Disease:
Serum total cholesterol measurement 		G 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs66476925
rs66476925
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs73066485
rs73066485
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		T 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs976517
rs976517
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0021704
Disease:
Intelligence 		0.700 GeneticVariation GWASCAT Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 29844566 2018
dbSNP: rs35803309
rs35803309
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C3812686
Disease:
Interleukin 1 Receptor Antagonist Measurement 		AT 0.700 GeneticVariation GWASCAT Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. 27989323 2017
dbSNP: rs4487645
rs4487645
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0268381
Disease:
Primary amyloidosis 		C 0.700 GeneticVariation GWASCAT Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. 28025584 2017
dbSNP: rs7971
rs7971
Entrez Id: 8701;55536
Gene Symbol: DNAH11;CDCA7L
DNAH11;CDCA7L
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs757784023
rs757784023
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0008780
Disease:
Ciliary Motility Disorders 		T 0.700 CausalMutation CLINVAR Diagnosis of Primary Ciliary Dyskinesia by a Targeted Next-Generation Sequencing Panel: Molecular and Clinical Findings in Italian Patients. 27637300 2016
dbSNP: rs200693106
rs200693106
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0008780
Disease:
Ciliary Motility Disorders 		T 0.700 CausalMutation CLINVAR Carrier frequencies of eleven mutations in eight genes associated with primary ciliary dyskinesia in the Ashkenazi Jewish population. 25802884 2015
dbSNP: rs368260932
rs368260932
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0008780
Disease:
Ciliary Motility Disorders 		T 0.700 CausalMutation CLINVAR Whole-Exome Sequencing and Targeted Copy Number Analysis in Primary Ciliary Dyskinesia. 26139845 2015
dbSNP: rs55649657
rs55649657
Entrez Id: 8701;105375183
Gene Symbol: DNAH11;LOC105375183
DNAH11;LOC105375183
CUI: C1445957
Disease:
Serum total cholesterol measurement 		G 0.700 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015
dbSNP: rs56130071
rs56130071
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		C 0.700 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015