CDH1, cadherin 1, 999

N. diseases: 508; N. variants: 187
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9929218
rs9929218
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE We demonstrate the potential of common inherited genetic variants to inform patient outcome and show that rs9929218 identifies approximately 8% of colorectal cancer patients with poor prognosis. rs9929218 may affect CDH1 expression and E-cadherin plays a role in epithelial-to-mesenchymal transition providing a mechanism underlying its prognostic potential.Clin Cancer Res; 21(15); 3453-61.©2015 AACR. 25873087 2015