|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of the C7</span>9G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs. CC: OR, 0.69; 95% CI, 0.55-0.88) and the recessive model (GG vs. CC+CG: OR, 0.65; 95% CI, 0.53-0.81).
|
31142730 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the age stratification analysis, C79G polymorphism owned a reduced effect on asth</span>ma risk for children (GG vs. CC: OR=0.69, p=0.002; GG vs. CC+CG: OR=0.65, p<0.001).
|
31115019 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that the ADRB2 rs1042714 polymorphism has a protective association with asthma in the overall population and the pediatric subgroup.
|
31699066 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma.
|
25985706 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Serbian adults, carriers of the 27Gln allele and 27Gln/Gln genotype were at higher risk of asthma [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.6-3.8, and OR 3.00, 95% CI 1.7-5.3, respectively], while the presence of the 27Glu allele and 27Gln/Glu genotype were found to be protective of asthma (OR 0.4, 95% CI 0.3-0.6, and OR 0.3, 95% CI 0.1-0.7, respectively).
|
25074500 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.
|
24992184 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the group of mestizo schoolchildren studied, the Arg16Gly and Gln27Glu polymorphisms are not markers of susceptibility or severity of asthma and do not affect ADRB2 gene expression during the rescue therapy.
|
22328447 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).
|
22075484 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Eleven single nucleotide polymorphisms (SNPs) in CHRM1-3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding beta(2) adrenoreceptor) were scored in 80 of the 138 asthmatics.
|
19183167 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu27Gln polymorphism had no significant effect on asthma exacerbations in any treatment group.
|
16772309 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we examined the variability of definitions of endpoints and analyses reported across studies addressing the association of the Arg16Gly and/or Gln27Glu polymorphisms of the beta2-adrenergic receptor gene with clinical response to beta2-agonist therapy in asthma.
|
17001289 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes.
|
15987731 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asthmatics heterozygous for Gln/Glu27 had significantly later asthma onsets than those homozygous for Gln27.
|
10524541 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects.
|
10469027 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |