|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients.
|
24941225 |
2014 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The FUT2 non-secretor allele showed genome-wide significant association with CD in Koreans (rs1047781, odds ratio [OR] = 1.30, P<sub>combined</sub> = 3.52 × 10<sup>-12</sup> ).
|
31260595 |
2020 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study strongly implicates the polymorphic locus of FUT2 (rs1047781) in CD susceptibility in Chinese population.
|
24720527 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for other covariant, we observed that betel quid chewing among 1255 smokers who carrying at least one C genotype (TC and CC) at rs281377 and least one T genotype (TA and TT) at rs1047781 were exhibited synergistic effects of environmental factors (betel quid and cigarette use) on the susceptibility of oral cancer.
|
26646561 |
2016 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study strongly implicates the polymorphic locus rs1047781 of <i>FUT2</i> as being associated with HCC development.
|
28824326 |
2017 |
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for other covariant, we observed that betel quid chewing among 1255 smokers who carrying at least one C genotype (TC and CC) at rs281377 and least one T genotype (TA and TT) at rs1047781 were exhibited synergistic effects of environmental factors (betel quid and cigarette use) on the susceptibility of oral cancer.
|
26646561 |
2016 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients.
|
24941225 |
2014 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the wild-type genotype at SNP rs1047781, which is homozygous for nucleotides AA, at least one polymorphic T allele (AT or TT) displayed significant association with clinical stage (<i>p</i> = 0.048) and tumor size (<i>p</i> = 0.022).
|
28824326 |
2017 |
|
Psoriasis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
The sCEA level in rs1047781-T carriers was higher than that in the A carriers in CRC patients without lymph node metastasis (P = 0.006).
|
24941225 |
2014 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TT homozygous rs1047781 frequencies were lower in the UC groups than in the controls (9.5% vs 11.8% and 4.0% vs 6.7%). rs601338 was statistically related to UC in both populations (Han, P = 0.025; Uyghur, P = 8.33 × 10(-5)).
|
23002346 |
2012 |
|
VITAMIN B12 MEASUREMENT
|
|
0.800 |
GeneticVariation
|
GWASDB |
In addition, we also confirmed the association with the serum level of VitB12 for the previously reported FUT2 gene and identified one novel non-synonymous single-nucleotide polymorphism in FUT2 gene in this Chinese population (19q13.33; rs1047781; P= 3.62 × 10(-36)).
|
22367966 |
2012 |
|
VITAMIN B12 MEASUREMENT
|
|
0.800 |
GeneticVariation
|
GWASCAT |
In addition, we also confirmed the association with the serum level of VitB12 for the previously reported FUT2 gene and identified one novel non-synonymous single-nucleotide polymorphism in FUT2 gene in this Chinese population (19q13.33; rs1047781; P= 3.62 × 10(-36)).
|
22367966 |
2012 |