|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) within the lysyl oxidase like-1 gene (LOXL1; rs1048661 and rs3825942) were found to confer risk to pseudoexfoliation glaucoma (XFG) through the pseudoexfoliation syndrome (XFS) in Nordic, Caucasian, and two Asiatic populations (Indian and Japanese).
|
19503743 |
2009 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNPs of LOXL1 (rs1048661; Arg141Leu and rs3825942; Gly153Asp) are highly associated with XFS in the Japanese population.
|
18648524 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
However rs1048661 SNP did not show an association with XFS.
|
24892565 |
2016 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our previous data suggested that three single-nucleotide polymorphisms (SNPs), rs1048661, rs3825942, and rs2165241, of the lysyl oxidase-like 1 gene (<i>LOXL1</i>) are significantly associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG).
|
31192002 |
2019 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of G allele in R141L and G153D SNPs of the LOXL1 gene did not differ between XFS/XFG patients with and without CVD, but its frequency was different in XFS/XFG and ischemic stroke.
|
20436359 |
2011 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of the G allele in the exonic SNP (rs1048661</span>) appeared to be higher in XFS or XFG patients compared to control subjects (<i>P</i>= 0.0497).
|
31850260 |
2019 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicates that rs1048661 ("G" alleles) had weak association with XFG/XFS; rs3825942 ("G" alleles) had strongly association with XFG/XFS; and rs2165241("T" alleles) had significant risk with XFG/XFS in some ethnicity.
|
25304275 |
2016 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Frequencies of the T allele of rs1048661 and the G allele of rs3825942 were significantly higher in XFS patients than in control subjects (rs1048661: 99.4% versus 55.0%; rs3825942: 99.4% versus 85.3%; p<0.0001).
|
18636115 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similar to almost all non-African populations tested thus far, the "G" allele of both rs1048661 and rs3825942 SNPs were associated with the risk of PEG in the Saudi Arab population.
|
21197115 |
2010 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated with increased risk for XFS and exfoliation glaucoma (XFG).
|
18483563 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the association of three LOXL1 variants (rs1048661, rs3825942, and rs2165241) in 142 Japanese patients with exfoliation syndrome (EX; n=59) and exfoliation glaucoma (EG; n=83) as well as in 251 control patients aged 70 years or older with primary open-angle glaucoma (PG; n=40), normal tension glaucoma (NG; n=54), and cataract (CT; n=157).
|
18958304 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Compared with the CT group, subgroup analysis showed that the CRVO EX+ group had significant differences in the allelic and genotypic frequencies of rs1048661 (p = 0.0006447 and p = 0.0001392, respectively) and had borderline differences in the allelic and genotypic frequencies of rs3825942 (p = 0.03403 and p = 0.07341, respectively), while the CRVO EX- group did not (p = 0.1324-0.6306).
|
25130441 |
2015 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The SNPs rs1048661 and rs3825942 of the LOXL1 gene seem to be highly associated with XFS in the Japanese population, but a different polymorphism of LOXL1 may cause the development of XFS in the Japanese population.
|
18201684 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma did not show any genetic association with either single-nucleotide polymorphism rs1048661 or rs3825942.
|
30189755 |
2019 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In both case-control and family materials, significant association for allele G of rs1048661 (P=2.65 x 10(-5); P=0.0007), allele G of rs3825942 (P=2.24 x 10(-8); P=0.49) and allele T of rs2165241 (P=2.62 x 10(-13); P<0.0001) was found in XFS/XFG.
|
19343041 |
2009 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings of the current study indicate that in a logistic regression analysis model the T allele of rs1048661 is the most important risk-modifying factor for the development of XFS and XFG.
|
23378724 |
2013 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 x 10(-40); rs1048661, OR = 2.43, P = 2.90 x 10(-19); and rs3825942, OR = 4.87, P = 8.22 x 10(-23)).
|
18385063 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition the G alleles of rs1048661 and rs3825942 confer an increased risk for PEXG with an odds ratio (OR) of 2.98 (95% CI 1.94-4.57) and OR 6.83 (95% CI 2.94-16.67), respectively.
|
22605916 |
2012 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicated that rs1048661 TT carriers had 92.1% and 40.4% less risk of developing PEXS/PEXG than did the controls in the Caucasian and Asian populations, respectively.
|
24603551 |
2014 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the Thessaloniki Eye Study, the G153D SNP of LOXL1 gene was strongly associated with both PEX and PEXG, whereas the R141L was not associated.
|
24917141 |
2014 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the Icelandic and Swedish populations, pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) has been significantly associated with LOXL1 exon 1 polymorphisms - allele G of rs1048661 (R141L) and allele G of rs3825942 (G135D).
|
18334947 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the functional effects of the LOXL1 SNP appear to be qualitative rather than quantitative, the amino acid substitution (R141L) caused by SNP rs1048661 is not a simple decisive factor for XFG due to the inverted allele frequency between Japanese XFG and Caucasian XFG patients.
|
18552979 |
2008 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of XFS and XFG with G153D appeared to be less powerful in this population (XFS: odds ratio [OR]=2.162, p=0.039, XFG: OR=2.794, p=0.002) compared to other populations, and for R141L, the association was proven only with XFG (OR=3.592, p<0.001).
|
23687437 |
2013 |
|
Exfoliation Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two non-synonymous single-nucleotide polymorphisms of LOXL1, R141L (rs1048661) and G153D (rs3825942), have been reported to significantly increase susceptibility to exfoliation glaucoma (XFG).
|
22328822 |
2012 |