|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
A case-control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls.
|
23754344 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
A hospital-based case-control study of 684 ESCC patients and 1064 healthy controls was performed to assess the association between four previous reported IL-23R genotypes (rs6682925, rs6683039, rs1884444 and rs10889677) and ESCC risk.
|
24586528 |
2014 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
A subgroup analysis showed that the genetic models of rs10889677 polymorphism were associated with CD risk in Caucasians (p < 0.05), but not in Asians (p > 0.05).
|
31728561 |
2020 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
For rs10889677 in IL23R, the frequencies of the AA genotype and the A allele were statistical significant higher in breast cancer patients than in controls (P = 0.0084 and P = 0.0171, respectively), whereas the C allele was associated with an earlier age of breast cancer onset (50.6 years for AA, 48.7 years for AC and 46.0 years for CC (P = 0.0114)) in case-only study.
|
23239971 |
2012 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
For rs10889677 in IL23R, the frequencies of the AA genotype and the A allele were statistical significant higher in breast cancer patients than in controls (P = 0.0084 and P = 0.0171, respectively), whereas the C allele was associated with an earlier age of breast cancer onset (50.6 years for AA, 48.7 years for AC and 46.0 years for CC (P = 0.0114)) in case-only study.
|
23239971 |
2012 |
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
For the rs10889677 variant, the prevalence of the AA genotype and for the rs2201841, the CC genotype showed a more than two-fold increase in the AS group compared with the controls.
|
19522770 |
2009 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no evidence of a relationship between IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) and cancer risk was found in the overall population.Our meta-analysis provides no evidence supporting a global association of IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) with the risk of cancer.
|
26717375 |
2015 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no evidence of a relationship between IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) and cancer risk was found in the overall population.Our meta-analysis provides no evidence supporting a global association of IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) with the risk of cancer.
|
26717375 |
2015 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, rs10889677 may be associated with BC susceptibility and rs1884444 had association with HCC risk.
|
26717375 |
2015 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, rs10889677 may be associated with BC susceptibility and rs1884444 had association with HCC risk.
|
26717375 |
2015 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs10889677 may be associated with BC susceptibility and rs1884444 had association with HCC risk.
|
26717375 |
2015 |
|
Necrotizing enterocolitis in fetus OR newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, IL23R rs10889677 and IL17A rs2275913 were not associated with the susceptibility to NEC.
|
28224332 |
2017 |
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the IL17F (rs763780) and IL23R (rs10889677) polymorphisms did not show any association with RHD.
|
29985710 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL23R variants (rs11209026 and rs10889677) were not associated with T1D.
|
23579029 |
2013 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
In addition, the allelic (CD: p < 0.00001, OR = 1.34; UC: p < 0.00001, OR = 1.22) and dominant models (CD: p = 0.002, OR = 1.39; UC: p = 0.01, OR = 1.29), but not the recessive model of rs10889677 polymorphism significantly increase the risk of CD and UC (p > 0.05).
|
31728561 |
2020 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our results demonstrate that rs10889677 polymorphism is significantly associated with CRC risk.
|
31546198 |
2019 |
|
Sjogren's Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our study, we genotyped groups of patients with AS (n = 206), SS (n = 156) and healthy controls (n = 235) for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, rs11209026, rs10489629, rs7517847 and rs7530511 variants using PCR-RFLP methods.
|
19522770 |
2009 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), -197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population.
|
28547498 |
2017 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Lack of association between rheumatoid arthritis and genetic variants rs10889677, rs11209026 and rs2201841 of IL-23R gene.
|
29370888 |
2018 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed that bearing these alleles represent risk for the development of rheumatoid arthritis (chi(2) = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and chi(2) = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841).
|
17606463 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed independent CD association for carriers of ATG16L1 (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.09-3.24), IBD5-IGR2230 (OR = 2.16, 95% CI 1.30-3.59), and IL23R-rs10889677 (OR = 2.13, 95% CI 1.39-3.28) while retaining association for NOD2 mutation carriers (OR = 4.45, 95% CI 2.68-7.38), IBD family history (OR = 2.75, 95% CI 1.42-5.31), tobacco (OR = 2.06, 95% CI 1.35-3.14), and Jewish ethnicity (OR = 20.1, 95% CI 2.16-186.8).
|
18521914 |
2008 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data emphasise that the AA genotype of rs11209026 (Arg381Gln) was significantly associated with RA patients compared to the controls (P value=0.001).We did not find any significant association between either rs2201841 or rs10889677 and the development of rheumatoid arthritis (P value=1.000 & 0.562 respectively).
|
25858864 |
2015 |