|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
CONCLUSIONS; The BRAF V600E mutation was present in all patients with HCL who were evaluated.
|
21663470 |
2011 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL).
|
21910720 |
2011 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BRAF-V600E was detected at different time points during the disease course, even after therapy, pointing to its pivotal role in HCL pathogenesis and maintenance of the leukemic clone.
|
22028477 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the BRAF V600E mutation is present in all patients with HCL and that, in combination with clinical and morphologic features, represents a reliable molecular marker for this condition.
|
22072557 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hairy cell leukemia has been shown to be strongly associated with the BRAF V600E mutation.
|
22133769 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation.
|
22210875 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the BRAF V600E mutation was uniformly identified in one HCL series, which may provide insights into the pathogenic mechanisms.
|
22212971 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, in conjunction with prior data, our results suggest incorporation of BRAF V600E mutation analysis in the diagnostic workup of HCL cases.
|
22246856 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A high degree of correlation was noted between the presence of BRAF V600E and established diagnostic criteria in 26/27 patients with HCL/HCL variant.
|
22313586 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diagnostically, the BRAF(V600E) mutation is a powerful molecular marker for papillary thyroid carcinoma and, quite possibly, hairy cell leukemia as well.
|
22369373 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia.
|
22531170 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, our pyrosequencing-based assay provides a convenient, rapid, sensitive, and quantitative tool for the detection of BRAF p.V600E mutations in HCL for clinical diagnostic testing.
|
22706871 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas.
|
23161722 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the presence of pERK as detected by immunohistochemical staining is a useful surrogate marker for BRAF V600E in the diagnosis of HCL.
|
23211289 |
2013 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conversely, all 44 cases with neoplasms mimicking hair</span>y cell leukemia were devoid of BRAF-V600E</span> and none expressed phospho-ERK.
|
23349307 |
2013 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, SkE resensitized the PLX-4032-resistant 451Lu melanoma cell line (451Lu-R) and was more efficient than U0126, a MEK inhibitor, and PLX-4032 (PLX) at inducing the apoptosis of two hairy cell leukemia (HCL) patient samples carrying the B-Raf-V600E mutation.
|
23518796 |
2012 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
An extensive number of studies have documented the V600E mutation in nearly all HCL patients, but not in similar hematologic malignancies.
|
23892906 |
2013 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two V600E-negative HCL contained novel, potentially functionally relevant mutations in exon 11 (F468C and D449E), while one other HCL was BRAF wild-type in exons 2-17.
|
24433452 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of these results, an assay with high analytic sensitivity is required for the clinical detection of V600E mutations in HCL specimens.
|
24503706 |
2015 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Advanced molecular techniques have identified distinct molecular aberrations in the Raf/MEK-ERK pathway and BRAF (V600E) mutations that drive the proliferation and survival of HCL B cells.
|
24652320 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.
|
24689848 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Discovery of the BRAF V600E mutation as a disease-defining genetic event in hairy cell leukemia can be helpful in both differential diagnosis and treatment of this disease.
|
24789721 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 2011, the V600E mutation of the BRAF gene in exon 15 was identified in HCL; being present in HCL, it is absent in the variant form of HCL (HCL-v) and in splenic red pulp lymphoma (SRPL), two entities related to HCL.
|
24994538 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
RAF is among the most frequently mutated kinases, where BRAF V600E mutation occurs in most hairy cell leukemias (HCL) and half of malignant melanomas.
|
25034364 |
2014 |
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, immunohistochemical detection of the BRAF V600E mutant protein is highly sensitive and specific for the diagnosis of HCL.
|
25120816 |
2014 |