rs120074192, KCNQ1

N. diseases: 10
Disease: Cardiac Arrhythmia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cardiac Arrhythmia
CUI: C0003811
Disease: Cardiac Arrhythmia
0.030 GeneticVariation BEFREE We have investigated mechanisms by which the S1 domain S140G KCNQ1 mutation influences atrial arrhythmia risk and, additionally, whether it can affect ventricular electrophysiology. 24411289 2014
Cardiac Arrhythmia
CUI: C0003811
Disease: Cardiac Arrhythmia
0.030 GeneticVariation BEFREE In conclusion, increased I(Ks) due to the KCNQ1 S140G mutation increases atrial susceptibility to arrhythmia due to increased tissue vulnerability, shortened ERP and altered atrial conduction velocity, which, in combination, facilitate initiation and maintenance of re-entrant excitation waves. 22508963 2012
Cardiac Arrhythmia
CUI: C0003811
Disease: Cardiac Arrhythmia
0.030 GeneticVariation BEFREE The purpose of this study was to further explore the association of the KCNQ1 S140G mutation with cardiac arrhythmias. 17467630 2007