rs121434568, EGFR

N. diseases: 73
Disease: Non-squamous non-small cell lung cancer ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Non-squamous non-small cell lung cancer
CUI: C4324656
Disease: Non-squamous non-small cell lung cancer
0.020 GeneticVariation BEFREE Differential efficacy of cisplatin plus pemetrexed between L858R and Del-19 in advanced EGFR-mutant non-squamous non-small cell lung cancer. 29291705 2018
Non-squamous non-small cell lung cancer
CUI: C4324656
Disease: Non-squamous non-small cell lung cancer
0.020 GeneticVariation BEFREE Activating mutations in the EGFR gene (deletions in exon 19 and mutation L858R in exon 21), first described in 2004, have been detected in approximately 10% of all non-squamous non-small cell lung cancer (NSCLC) patients in Western countries and are the most important predictors of a response to EGFR tyrosine-kinase inhibitors (EGFR-TKIs). 26398757 2016